Most patients with prostate cancer inevitably progress to castration-resistant prostate cancer (CRPC), at which stage chemotherapeutics like docetaxel become the first-line treatment. However, chemotherapy resistance typically develops after an initial p
Loss of functional E-cadherin, and thus of adherens junction-mediated cell-cell contacts was reported to be the first step of tumor invasion and metastasis in various cancers33. Snail encoded by SNAI1/SNA gene binds to the promoter of E-cadherin gene and represses its transcription34. ...
HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected cells. Previous studies have shown that natural killer cells are important to inhibiting HIV infection, but it is unclear whether the administration of na
ABCA1, a cholesterol transporter expressed in the brain, has been shown recently to be required to maintain normal apoE levels and lipidation in the central nervous system. In addition, ABCA1 has been reported to modulate β-amyloid (Aβ) production in vitro. These observations raise the ...
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62 Although this has not been clearly demonstrated to be the same in those with HIV, we and others speculate that antiviral therapy will accomplish the same positive outcome.63 In the developed world during the pre-HAART era, increasing access to HCV antiviral therapy made little sense given ...
What would that be worth to you? * Other Phytoceramide Brands might look the same, but cheaper 350mg LipoWheat or Sweet Potato Phytoceramides do not work the same. They cannot compare to the Supe...
It was a New Year's bowl game in Florida for a second straight year, which is huge in a state that really matters to the Hoosiers. There are nearly two dozen players from Florida on the roster, with more to come. Game embraced, but a victory had to be embraced too, and that didn...
occur from being the empathic and caring therapist to the tired, preoccupied family member; in fact, Simpson et al. (2018), in their sample of 443 clinical and counselling psychologists found the juggling of the work-life balance to be the most distressing work related stressor amongst this ...
heart valves in a dose-dependent manner, and a 40% sucrose solution was found to be sufficient to diminish pore formation. The presence of pores in freeze-dried valves altered biomechanical characteristics, but did not affect the overall structure and heat stability of the extracellular matrix ...