Dilantin ToxicityMedically reviewed by Drugs.com. Last updated on Mar 10, 2025.Care notes Aftercare Ambulatory Español Dilantin, or phenytoin, toxicity happens when you have high levels of Dilantin in your body that become harmful. Dilantin is a medicine that is used to prevent and treat ...
Dilantin toxicity: a clinical and electroencephalo- graphic study. Neurology 1961;11:912-21.Roseman, E. ( 1961 ): Dilantin toxicity. A clinical and electroencephalographic study . Neurology 11 , 912 – 921 .Rosemann E. Dilantin toxicity: a clinical and electroencephalo- graphic study. ...
Have kidney or liver problems as you may show early signs of toxicity. DILANTIN may cause liver damage Have or had porphyria (por-FER-ee-ah). DILANTIN has been associated with harmful effects on blood cells Have or had diabetes. Your blood sugar level can be altered while taking DILANTIN ...
and are obtained just prior to the patient's next scheduled dose. Peak levels indicate an individual's threshold for emergence of dose-related side effects and are obtained at the time of expected peak concentration. Therapeutic effect without clinical signs of toxicity occurs more often with serum...
Drugs that increase phenytoin blood levels and toxicity include: acute alcohol intake, amiodarone (Coradone), chlordiazepoxide, cimetidine (Tagamet), diazepam (Valium, Diastat), dicumarol, disulfiram, estrogens, ethosuximide, fluoxetine (Prozac), fluorouracil, fluvoxamine (Luvox), ...
The most notable signs of toxicity associated with the intravenous use of this drug are cardiovascular collapse and/or CNS depression. Hypotension does occur when the drug is administered rapidly by the intravenous route. The rate of administration is very important; it should not exceed 50 mg per...
When taking phenytoin, it is important to monitor blood levels of the medication to ensure they remain within the therapeutic range, as both low and high levels can lead to seizures or toxicity, respectively. Additionally, regular monitoring of liver function and complete blood counts is recommended...
Antibiotic Medication Allergy Antiretroviral Medication Allergy Digoxin Toxicity Dilantin Toxicity Lithium Toxicity Safe Use of Antiplatelet MedicationFurther information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Medical...
Because phenytoin is highly protein bound and only unbound drug is capable of crossing the blood-brain barrier to exert its pharmacologic effect, unbound (free) phenytoin levels may be more clinically relevant than total levels to maximize efficacy and minimize toxicity.3,4 ...
Accordingly, at the first sign of acute toxicity, plasma levels are recommended. Dose reduction of phenytoin therapy is indicated if plasma levels are excessive; if symptoms persist, termination is recommended. (see WARNINGS section.) Information For Patients Inform patients of the availability of a...