Most recently, dihydropyridine deaths have increased. While there are established models of nondihydropyridine poisoning there currently are no established experimental models of dihydropyridine poisoning.David JangSean DonovanTheodore BaniaLewis NelsonRobert HoffmanJason Chuother...
For this reason, the clinical utility of nondihydropyridine CCBs is their negative inotropic and chronotropic action on the heart, whereas the vasodilating properties of the dihydropyridines (e.g., amlodipine) make them preferred for the treatment of hypertension. Numerous studies have confirmed that ...
Bakris GL, Copley JB, Vicknair N, Sadler R, Leurgans S . Calcium channel blockers versus other antihypertensive therapies on progression of NIDDM associated nephropathy.Kidney Int1996;50: 1641–1650. CASPubMedGoogle Scholar Bakris GL, Copley JB, Vicknair N, Sadler R, Leurgans S . Calcium cha...
Cardiac versus vascular effects of a new dihydropyridine derivative, CV-4093. In vitro comparison with other calcium antagonists. The effects of CV-4093, a new dihydropyridine derivative, on isolated cardiovascular tissues were compared with those of several dihydropyridine and non-di... H Nakaya,Y...
The adenosine A2B receptor is a critical protein in intestinal water secretion. In the present study, we screened compound libraries to identify inhibitors of the A2B receptor and evaluated their effect on adenosine-induced intestinal fluid secretion. Th
4). Only ortho chloro derivative and non substituted phenyl analogues were effective hypotensive agents. The dichloro derivative and coumarine analogue did not show a comparable activity. DHP I does not affect the heart rate. DHP II and III show initial tachycardia but later show a gradual ...
Disclosed are 1,4-dihydropyridine immunogen conjugates of immunogenic carrier materials coupled to a 1,4-dihydropyridine derivative. Said conjugates are useful for the preparation of antibodies theret
With these studies it became evident that the NO-releasing effect was not unique to nitrendipine but was a group phenomenon shared by the dihydropyridines and several nondihydropyridine calcium antagonists. In addition to their action on vascular endothelium, NO release by nifedipine has also been ...
Objective: To investigate the clinical outcomes from dihydropyridine overdoses with ARBs/ACEIs versus dihydropyridine overdoses alone. Methods: This was a retrospective study of patients reported to the New South Wales Poisons Information Centre (NSW PIC) and 3 toxicology units (Jan 2016 to Jun ...
With these studies it became evident that the NO-releasing effect was not unique to nitrendipine but was a group phenomenon shared by the dihydropyridines and several nondihydropyridine calcium antagonists. In addition to their action on vascular endothelium, NO release by nifedipine has also been ...