Estimation of optimal dose showed that the doses recommended in intoxicated patients should be 3.5 times lower to reach the therapeutic range. Conclusion Digoxin concentrations were higher in patients with toxicity. Older age enhanced the risk of digoxin toxicity. Monitoring digoxin concentrations may ...
Therapeutic range of digoxin in patients to be used as a reference was 0.9 to 2.3 ng/ml. Results: Twenty-one patients showed both clinical and ECG signs of digoxin toxicity, 19 patients had only a single manifestation and 155 did not present with any of these manifestations. Although the ...
Both patients experienced these symptoms while receiving digoxin.Both patients had digoxin blood levels in the therapeutic range (1.7 and 1.0 ng/ml, respectively). Therapeutic levels are 0.5 to 2.0 ng/ml. After discontinuing digoxin, the first patient noted that the shimmering light symptoms ...
Free Essay: Question 1: Digoxin toxicity. Digoxin has a narrow therapeutic index and chronic toxicity is more likely in the elderly and those with renal...
The therapeutic index is very low. The therapeutic range for digoxin is 0.5 to 2.5 nmol/L (in the blood). The probability of toxicity is significant when the level is > 2.6, and toxicity is virtually guaranteed when the level is >3. Contrast this to acetaminophen (Tylenol), in which the...
Discussion In an early but influential study that helped establish the therapeutic range for digoxin, Smith et al5 reported digoxin toxicity based on electrocardiographic (ECG) manifestations. In the 0.80 to 2.4 ng/mL range, patients without evidence of ECG changes were considered to have nontoxic ...
Digoxin is a cardioactive drug with a narrow therapeutic range. Therapeutic drug monitoring is essential in clinical practice for efficacy as well as to avoid digoxin toxicity. Immunoassays are commonly used in clinical laboratories for determination of serum or plasma digoxin concentrations. Unfortunately...
Thirty-nine patients had measured digoxin levels drawn; 28 (71.8%) were in the therapeutic range (0.5-2.1 ng/mL), and four (10.2%) were in the toxic range (> 2.1 ng/mL). The patients with toxic dogoxin levels and those with nontoxic levels had similar resuscitation rates (50.0% vs....
Because the difference between the therapeutic concentration range and toxic concentrations is very small, digoxin toxicity can easily occur. Digoxin toxicity results predominantly in ocular symptoms(such as xanthopsia, photophobia, hazy vision, visual loss, and central scotoma), digestive symptoms(such ...
Patients with AV nodal dysfunction, serum digoxin concentrations in the upper end of the therapeutic range, and/or high plasma flecainide concentrations may be at increased risk of digoxin toxicity Monitor for signs of digoxin toxicity Gentamicin Increased serum digoxin concentrations by 129–212%...