Open Document Question 1: Digoxin toxicity. Digoxin has a narrow therapeutic index and chronic toxicity is more likely in the elderly and those with renal impairment. Since Mr Buchanan is 75 years old, he may already have some form of renal impairment and therefore is at a higher risk of de...
Monitor for signs and symptoms of digoxin toxicity and clinical response. Adjust dose based on toxicity, efficacy, and blood levels. Serum digoxin levels < 0.5 ng/mL have been associated with diminished efficacy, while levels above 2 ng/mL have been associated with increased toxicity without incre...
The recommended starting maintenance doses in adults and pediatric patients over 10 years old with normal renal function are given in Table 2. Doses may be increased every 2 weeks according to clinical response, serum drug levels, and toxicity. ...
According to recent studies in the United States, digoxin toxicity presents in 10%-18% of nursing home residents.[10]This condition also presents in 1.1% of outpatient and 0.4% of all hospitalized patients.[10]The incidence of glycoside toxicity and subsequent use of digoxin therapy has decrease...
hazy vision, and arrhythmia [3,25]. The latter three are not typical of digoxin toxicity in younger populations (anorexia and vomiting) and are consistent with numerous other physiological or pathological process in the elderly (poor specificity) making diagnosis of toxicity difficult [10,19,30]....
Monitor for pro-arrhythmic effects, especially with digoxin toxicity. Use caution in patients with acutemyocardial infarction; may increase myocardial oxygen demand; during acute coronary syndrome, digoxin administered intravenously (IV) may be used to slow a rapid ventricular response and improve left ...