Digoxin antibody fragments (Digibind tm , Wellcome) have now been used in 97 patients with suspected life threatening digoxin or digitoxin toxicity. In most cases therapeutic response has been prompt and complete. There have been no unexpected side effects noted in these very sick patients. ...
Digoxin specific antibody fragments (Digibind) are indicated but can falsely raise digoxin levels. The administration of a further dose of Digibind should be guided by the patient's symptoms rather than the digoxin level.doi:10.1136/bmj.b2884Ip, Dorothy...
Context. Digoxin-specific antibody fragments (digo Chan,SH B.,Buckley,... - Clinical toxicology: the official journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists 被引量: 35发表: 2014年 Treatment of severe digitalis intoxication...
( 1989 ) Kinetics of digoxin and digoxin-specific antibody fragments during treatment of digoxin toxicity . Br. J. Clin. Pharmacol. 28 : 352 – 356 .Sinclair AJ, Hewick DS, Johnston PC, et al. Kinetics of digoxin and anti-digoxin antibody fragments during treatment of digoxin toxicity. Br...
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Digoxin immune Fab fragments (e.g. Digibind® from Glaxo SmithKline) are a promising treatment for life-threatening digoxin toxicosis. The Fab fragments are used as a specific antidote for digoxin since they inactivate the drug by directly binding to it. The fragments are produ...
Digoxin-specific antibody Fab fragments in childrenInpharma Weekly -doi:10.2165/00128413-199208440-00048NoneSpringer International PublishingInpharma Weekly
digoxin toxicity is more common in renal failure because excretion is greatly affected. Digoxin-specific antibody fragments (Dig-Fab) are considered as first-line therapy for digoxin toxicity. In addition,gastric lavage, atropine, and cardiac pacing may be needed.Antiarrhythmics, such as lidocaine or...
A patient with renal failure due to myeloma kidney and coincident digitalis intoxication due to prescribed daily digoxin administration was treated with digoxin-specific antibody fragments and plasmapheresis. Rapid response to therapy was noted, removal of digoxin-antidigoxin antibody complexes was confirmed...
— The plasma kinetics of total and free digoxin, and digoxin-specific antibody fragments (DSFab) in rabbits which had been given [3H]digoxin one hour before DSFab has been studied over a 5 day period. Injection of DSFab caused a 4- to 5-fold rise in total digoxin and reduced eliminati...