Digoxin antibody fragments (Digibind tm , Wellcome) have now been used in 97 patients with suspected life threatening digoxin or digitoxin toxicity. In most cases therapeutic response has been prompt and complete. There have been no unexpected side effects noted in these very sick patients. ...
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Plasma exchange for the removal of digoxin-specific antibody fragments in renal failure: Timing is important for maximizing clearance Life-threatening digoxin toxicity may be effectively treated with digoxin-specific antibody fragments (Fab). However, in end-stage renal disease, the digox... M Zdunek...
34 patients aged between 2 and 80 years were treated with digoxin specific antibody (Fab) fragments for severe digitalis poisoning. In 27 cases, the glycoside was taken with suicidal intent; in 3 cases accidentally and 4 were iatrogenic. The following criteria were considered to be indications fo...
Digoxin-specific antibody Fab fragments in childrenInpharma Weekly -doi:10.2165/00128413-199208440-00048NoneSpringer International PublishingInpharma Weekly
Digoxin-specific antibody Fab fragments are effective in the management of digitalis intoxication. However, in patients with severe renal impairment the clearance of antibody–digoxin complexes is reduced, and rebound toxicity can occur if the cardiac glycoside dissociates from the antibody. Removal of ...
Chan BS, Buckley NA. Digoxin-specific antibody fragments in the treatment of digoxin toxicity. Clinical toxicology (Philadelphia, Pa.). 2014 Sep-Oct:52(8):824-36. doi: 10.3109/15563650.2014.943907. Epub 2014 Aug 4[PubMed PMID: 25089630] ...
The patient was treated empirically with a single dose of five vials (200 mg) of digoxin-specific Fab antibody fragments (Digibind). The pretreatment digoxin level was 1.5 ng/mL. After treatment, the patient's rhythm stabilized with residual sinus bradycardia (rate, 56). The patient recovered...
Treatment of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments: experience in 26 cases Purified Fab fragments of digoxin-specific antibodies obtained from sheep were used to treat 26 patients with advanced, life-threatening digoxin (23 cases) or digitoxin (3 cases) ...
Wenger TL, Butler VP, Haber E, Smith TW (1985) Treatment of 63 severely digitalis-toxic patients with digoxin-specific antibody fragments. J Am Coll Cardiol 5: 118A - 123A CrossRef About this Chapter Title Kinetics of the Fab fragments of digoxin antibodies and of bound digoxin in patie...