Medical reports of the neonates who had serum digoxin concentrations >2 nanogram/milliliter (ng/ml) were reviewed in terms of patient demographics, serum digoxin concentrations, signs and symptoms of digoxin toxicity, serum digoxin and electrolyte levels, renal function tests, electrocardiograms, ...
Digoxin toxicity is a significant clinical problem and is one of the reasons the drug is not as commonly used today as in the past. Toxic signs are often seen at roughly twice the minimum effective dose. In practice, adverse reactions usually result from accumulation of the drug or from K+...
Signs or symptoms of toxicity may not correlate well with digoxin levels. A normal level of digoxin does not rule out toxicity. ▪ The half-life is 30 hours in normal adults. ▪ Clearance is via the kidneys. Renal dysfunction increases the elimination half-time, which increases digoxin lev...
Peak digoxin body stores of 8 to 12 mcg/kg generally provide a therapeutic effect with minimum risk of toxicity in most patients with heart failure and normal sinus rhythm. The loading dose should be administered in several fractions, with approximately half the total given as the first dose. ...
Digoxin toxicityBackground: The striking similarities between signs and symptoms of digoxin intoxication and clinical picture of primary congestive heart failure (CHF) make their diagnosis relatively difficult. Narrow therapeutic window of digoxin and increasing mortality and morbidity due to its intoxication...
Not necessary to routinely reduce or hold digoxin therapy prior toelectiveelectrical cardioversion for atrial fibrillation; however, exclusion of digoxin toxicity is necessary prior to cardioversion; withhold digoxin and delay cardioversion until toxicity subsides if signs of digoxin excess exist. ...
In neonates, premonitory signs of toxicity may include sinus bradycardia, SA arrest, or prolongation of the PR interval.First-degree AV block is common and generally indicates a therapeutic rather than a toxic effect; AV block may progressively increase in patients with toxicity....
Her ECG showed changes indicative of digoxin toxicity (left bundle branch block and 1:2 heart block). Her digoxin concentration was elevated at 4.1 µg/L (6 hours since last dose). After admission, she was administered anti-digoxin polyclonal antibody. Her pulse then increased to 60bpm and...
The time course of the reversal of toxic and nontoxic effects of digoxin by digoxin-specific antibody fragments (Fab) was measured in isolated human ventricular myocardium. A concentration of 2脳10 6 mol/l digoxin was used to produce positive inotropy followed by mechanical signs of toxicity. ...
Free Essay: Question 1: Digoxin toxicity. Digoxin has a narrow therapeutic index and chronic toxicity is more likely in the elderly and those with renal...