It is classified as super toxic; an estimated single lethal dose is 3-10 mg. Digitoxoside emits acrid smoke and irritating fumes when heated to decomposition. View all 4.9 Toxicity Oral-Rat? LD50 23.75? mg/kg; Oral-Mouse LD50: 4.95 mg/kg...
Under a chronic treatment with a daily dose of 0.1 mg digitoxin in three out of seven individuals, detectable dihydrodigitoxin plasma levels were observed (0.7, 1.5, 1.7 ng/ml) (Table 7.1). On the other hand, in seven patients with renal failure, high dihydrodigitoxin plasma concentrations (...