In normal subjects, only minimal concentrations of dihydrodigitoxin in plasma could be determined (1 ng/ml) after an intravenous bolus injection of digitoxin. Under a chronic treatment with a daily dose of 0.1 mg digitoxin in three out of seven individuals, detectable dihydrodigitoxin plasma levels...
1 Nine healthy volunteers received single 1 mg intravenous doses of digitoxin, following which serum digitoxin concentrations were measured at multiple points in time over the next 14 days. 2 Mean kinetic variables for digitoxin were: volume of distribution, 0.76 l/kg; elimination half-life, 8 ...
The lethal doses of digitoxin, acetyldigitoxin and gitalin were determined in cats. Electrocardiograms were recorded intermittently during the course of the repeated injections of these glycosides. Their relative lethal activities in cats were found to be similar to the reported relative therapeutic ...
4. (4) Maintenance of patients in the compensated state was readily attained with an average daily 1 cc. (0.2 mg) dose of intramuscular digitoxin. 5. (5) Pain following intramuscular injection of the preparation was of minor consequence. There were no undesirable local or systemic effects and...
Female Sprague-Dawley rats were divided into 4 groups: Group A (control rats); Group B (rats receiving 0.15 mg of digitoxin per 100 g of body weight daily for 6 days of each week); Group C (swimming control rats); and Group D (swimming rats receiving digitoxin in the manner of Group...
Digitoxin (0.6 mg) was given as tablets or injection in the fasting state. A standard breakfast was given after 1/2 hour and a standard lunch after 3 1/2 hours. Blood samples were drawn after 0, 30, 60, 90 minutes and 2, 3, 4, 6 and 24 hours. Serum digitoxin concentrations were...
mg. protein. h-1. Retrograde injection of 0.5ml 1.4 times 10-4 mol.l-1 digitoxin into pancreatic ducts reduced pancreatic Na, K-ATPase activity by 31(18–47)%, while intra-arterial injection of 0.2 mg.kg b. wt-1 digitoxin reduced pancreatic Na, K-ATPase activity by 50(45–56)%. ...