Non-splice site mutations were observed in three diffuse type tumors, namely a 69-base pair deletion of exon 10 and two point mutations, one of which destroys a putative calcium binding region. Immunohistochemical evaluation showed E-cadherin immunoreactivity in tumors and lymph node metastases of ...
A case of diffuse-type tenosynovial giant-cell tumor of the temporomandibular joint Tenosynovial giant-cell tumors are classified into diffuse and localized types. The diffuse type develops primarily in major joints and rarely in the tempo... S Ohyama,C Ogawa,I Uchida,... - 《Nippon Koku Gek...
The less frequent diffuse-type giant cell tumors are commonly located in the periarticular soft tissues, but on rare occasions these lesions can be purely intramuscular or subcutaneous We report the case of a 26-year-old female with diffuse-type giant cell tumor of the subcutaneous thigh, ...
Synovial-type giant cell tumors of the vertebral column: a clinicopathologic study of 15 cases, with a review of the literature and discussion of the differential diagnosis. Hum Pathol 2003;34:670–679 CrossRef Motamedi K, Murphey MD, Fetsch JF et al. Villonodular synovitis (PVNS) of the ...
The intra-articular diffuse type can present as a large infiltrative mass involving adjacent soft tissue and sometimes causes secondary destruction of bone, which leads to radiographic and clinical concern for malignancy. The tumor may also be purely extra-articular. CASE: Here, we report the fine...
Diffuse-typegiantcelltumor - Hand - PigmentedvillonodularsynovitisDiffuse-type giant cell tumor (D-TGCT) is relatively rare. We report a case of multicentric D-TGCT located in the finger and wrist. A 79-year-old man presented with a more than two-year history of tumors. Marginal ...
Five patients had a clinical history of neurofibromatosis type 1, and 1 had Klippel-Trénaunay-Weber syndrome. Six tumors arose on the trunk and 1 each on the leg, arm, and scalp. Increased cellularity, nuclear atypia, and mitoses (range, 1 to 63/50 high-power fields) indicated transition...
Tenosynovial giant cell tumors (GCTs) typically form in the joints or extra-articular soft tissues such as the tendon sheath, and are benign tumors that commonly occur in the hands or wrists in the third to fifth decades of life. However, the diffuse type of extra-articular GCT arising wit...
For mutation altered proteome, up-regulated proteins in mutated tumor tissues are: (1) differential expressed in mutated tumors and wild-type tumors (P < 0.05, Wilcoxon rank-sum test); (2) mean value of mutated tumors/wild-type tumors >1.6. Down-regulated proteins are: (1) differential...
(RLT) may represent those with less immunosuppressive TMEs and fewer TAMs than cases enriched for MacroSig6 (DLBCL). This result also highlights that the application of a macrophage derived gene signature may remain clinically relevant in bulk gene-expression data from these tumors. Of particular ...