A skin biopsy was reported as diffuse large B-cell lymphoma. The histology revealed a diffuse infiltrate composed of a monotonous population of large round lymphocytes with features of centroblasts and immunoblasts. Immunostaining showed that the tumor cells were positive for CD20, MUM-1, FOX-P1,...
All these results suggested diffuse large B-cell lymphoma. CONCLUSIONS: Diffuse large B-cell lymphoma may primarily arise from the ciliary body and can develop without systemic or central nervous system disease.doi:10.1080/09273948.2017.1415362Hayyam Kiratli...
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma in the elderly and is increasing in incidence. Although significant therapeutic advances have recently been made in the care of older DLBCL patients, based upon results of randomized clinical trials, many olde...
DIFFUSE large B-cell lymphomasB cellsLYMPHOMASPurpose: To assess the prognostic significance of baseline neuroimaging for patients with secondary central nervous system (CNS) diffuse large B‐cell lymphoma (DLBCL). Methods: After obtaining institutional review board approval, we reviewed 44 patients ...
摘要: Summary This chapter contains sections titled: Clinical features Histology Immunophenotype Cytogenetics Differential diagnosis Prognosis and treatment Diffuse large B-cell lymphoma subtypes Other lymphomas of large B-cells Borderline cases Conclusion References...
Introduction: Diffuse Large B-Cell Lymphoma (DLBCL) is a heterogeneous group conformed by morphological and clinical varieties of neoplasms; it originates from peripheral B-cells and is distinguished into three groups: germinal center (GC), activated B lymphocyte (ABL), and the third type. The ...
Blood and Lymphatic Cancer: Targets and Therapy Dovepress open access to scientific and medical research Open Access Full Text Article R e v iew Treatment strategies for patients with diffuse large B-cell lymphoma: past, present, and future This article was published in the following Dove Press ...
An abdominal computed tomography scan revealed multiple intra-abdominal lymph nodes, which on histology proved diagnostic of diffuse large B-cell non Hodgkin's lymphoma. She received six cycles of R-CHOP chemotherapy, after which she achieved a complete metabolic response at all known previous sites...
(M-CLL)2. CLL transformation into a more aggressive histology is termed Richter syndrome (RS)3. Diffuse large B cell lymphoma (DLBCL) subtype accounts for 90–95% of RS cases. Around 80% of RS cases are IGHV-unmutated while the remainder are IGHV-mutated4. In contrast, most de novo ...
Newer, more effective and non-cytotoxic therapies are an unmet need for patients with diffuse large B-cell lymphoma (DLBCL) and other B-cell malignancies. Recently approved agents include polatuzumab with bendamustine and rituximab, selinexor, and tafasitamab plus lenalidomide. Three CAR-T cell pr...