This method is known as the derivative of a function from the first principle.Here \(f^{\prime}(x)=\frac{d}{d x}(f(x))\)If \(y=f(x)\), then it is denoted by \(\frac{d y}{d x}\), i.e. derivative of \(f(x)\)....
The geometrical meaning of the derivative of y = f(x) is the slope of the tangent to the curve y = f(x) at ( x, f(x)). The first principle of differentiation is to compute the derivative of the function using the limits. Let a function of a curve be y = f(x). Let us ...
Oligodendrocytes are generated via a two-step mechanism from pluripotent neural stem cells (NSCs): after differentiation of NSCs to oligodendrocyte precursor/NG2 cells (OPCs), they further develop into mature oligodendrocytes. The first step of this differentiation process is only incompletely understood...
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lack of PML-RARA mutation, although, in principle, terminal differentiation programs may still be activated by ATRA via the intrinsic retinoid signaling pathway. However, the differentiation-inducing capacity of ATRA in most cancer cell types has not been well characterized, in part, owing to the ...
We performed siRNA-induced transitory silencing of RXRα and RXRβ during first stages of neuronal differentiation of SH-SY5Y cells, and evaluated its effects for the main cellular responses to RA. Our results demonstrate that their expression is not equally required for RA effects and that they ...
In order to delete the differences in the data of various indicators, this paper first needs to normalize the original data [55]. If it is a positive indicator, Eq. (1) will be selected to standardize the data. On the contrary, If the variable is a negative indicator, Eq. (2) will...
There has also been some evidence that long-term PPI use might lead to the progression of atrophic gastritis and the development of gastric cancer [17, 18]. Since ancient times, traditional Chinese medicine (TCM), based on the theory of holism and the time-honored principle of differentiation...
First, IRBIT expression correlates with the EB maturation (Figure 2E). Second, IRBIT loss of function resulted in accumulation of EBs (R1+, Su(H)+ cells) (Figures 2 and 3). Third, suppression of IRBIT specifically in EB mirrored ΔIRBIT phenotype (Figure 3C). Fourth, suppression of RNR ...
Bonnafous A (2021) Analysis of the system of transport appraisal implemented in France and some methodological innovations. ITF Roundtable “Broadening Appraisal to Capture the Full Impact of Transport Investments” Cao W, Feng X, Zhang H (2019) The structural and spatial properties of the high-...