The incidence of acute promyelocytic leukemia appears constant over most of a human lifespan, implying only one rate limiting mutation. Leukemia 14, 722–726 (2000). Article CAS PubMed Google Scholar Welch, J. S. et al. The origin and evolution of mutations in acute myeloid leukemia. Cell...
For each partial derivative of the image, the anti-differentiation term biases the minimizer toward a function which integrates to the image up to an additive constant, while the regularization term biases it toward a function smooth everywhere except across image edges. A discretization of the ...
and the second stage is an unrestrained minimization of all the atoms in the simulation cell. The systems were then gently heated by incrementing the temperature from 0 to 300 K under a constant pressure of 1 atm and periodic boundary conditions. Harmonic restraints of 50 kcal/mol were...
immunosuppressive medications, and improved affected individual administration, kidney transplant rejection continues to be a significant concern that impacts long-term graft success [4]. Therefore, it is very important to build up effective ways of prevent and manage rejection in kidney transplant ...
usingAutoDiff;classProgram{publicstaticvoidMain(string[]args){// define variablesvarx=newVariable();vary=newVariable();varz=newVariable();// define our functionvarfunc=(x+y)*TermBuilder.Exp(z+x*y);// prepare arrays needed for evaluation/differentiationVariable[]vars={x,y,z};double[]values...
This complex history suggests that other origins of multicellularity may have involved important roles for cooperation, conflict and conflict mediation; parallel evolution of some traits; sporadic rather than constant change; and long-term coexistence of forms with different levels of complexity. Data ...
Pancreatic β cells differentiated from stem cells provide promise for cell replacement therapy of diabetes. Human pluripotent stem cells could be differentiated into definitive endoderm, followed by pancreatic progenitors, and then subjected to endocrin
Thus|\mathscr A\vec{x}|_mis an increasing function of|\vec{x}|_n. Given|\vec{x}|_n\leqslant 1, we have\sup_{|\vec{x}|_n\leqslant 1}{|\mathscr A\vec{x}|_m}=\sup_{|\vec{x}|_n= 1}{|\mathscr A\vec{x}|_m}. In fact, the last term is what we call theFrobenius ...
Here we handle the problem by an effective definition of the pressure function (section 2, assumption 5). The idea of the definition is, we try to approach the pressure to a constant function at such a rate as the material solidify. This paper is organized as follows. In section 2 we ...
Although the major task of the intermediate metabolism is to provide the cell with a constant supply of energy and molecular precursors for the production of biomolecules, the dynamic regulation of metabolic pathways also plays an active role in shaping T cell responses. Key metabolic processes such...