Alternatively-activated macrophages (AAMs), an anti-inflammatory macrophage subpopulation, have been implicated in the progression of high grade serous ovarian carcinoma (HGSOC). Increased levels of AAMs are correlated with poor HGSOC survival rates, and
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Figures (7) Show 1 more figure Tables (2) Table 1 Table Extras (3) Download all Document S1. Figures S1‒S Data S1. Differentially expressed genes between the different single-cell RNA sequencing clusters, related to Figure 3 Document S2. Article plus supplemental informationVolume...
RMS cells robustly express the myogenic transcription factorsMYODandMYOG, but yet are unable to terminally differentiate. Competition between MYOD and HEY1, TWIST1 and splice-forms of co-factor E2A have been shown to interfere with MYOD transcriptional activity and block terminal differentiation, howev...
Proportions of T cell progenitors in the thymus and mature CD4 and CD8 T cells in the spleen showed no significant difference between miR-669m-transduced cells and control vector-transduced cells (Fig. S2). Similarly, Pro-B (B220+IgM−CD43+CD19-), PrePro-B (B220+IgM−CD43+CD19+)...
or spss software. two-tailed student's t-test were used to compare two groups, and one-way anova analysis was used to compare three or more groups. the correlation between differentiation status and spheroid circularity were analyzed by the chi-square test. for survival analysis, the log-rank...
(barring mutation and a few rare exceptions), so that there is no obvious reason or genetic mechanism for cells to create new environments for one another. That all of these interactions between genetically identical cells should somehow work themselves out in the creation of many distinct ...
We independently performed differential expression analysis between the undifferentiated samples and the osteogenically induced hDPSCs and hBMSCs. The R package ‘limma’ was used to identify differentially expressed miRNAs. The normalised expression profiles of miRNAs in the control and experimental groups...
32These results raise the question concerning the involvement of the modulation of SERCA function in leukemia cell differentiation and suggest that a relation may exist between calcium homeostasis and retinoic acid–induced differentiation. In the present work, we studied the effect of pharmacologic ...
The balance between self-renewal and differentiation of LSCs is tightly controlled to ensure efficient corneal epithelial turnover and the maintenance of corneal homeostasis and transparency. The well-known LSC markers TP633, C/EBPD7, BCAM8, IFITM39 and ABCB510 are key regulators that maintain LSC...