Kupffer cellsMonocytesDifferentiationMacrophage colony-stimulating factor (M-CSFGranulomasKupffer cells are a proliferating resident macrophage population in the fetal and adult liver. Kupffer cells are derived
Cathepsin B regulates non-canonical NLRP3 inflammasome pathway by modulating activation of caspase-11 in Kupffer cells. Cell Prolif. 2018;51:e12487. Article PubMed PubMed Central CAS Google Scholar Lin XY, Choi MS, Porter AG. Expression analysis of the human caspase-1 subfamily reveals ...
To investigate whether IHCC cells can be converted to functional hepatocytes, we established organoids derived from human IHCC and cultured them under conditions suitable for hepatocyte differentiation. IHCC organoids after hepatocyte differentiation acquired functions of mature hepatocytes such as albumin ...
Monocytes traffic to sites of infection and differentiate into macrophages (MΦ) with distinct phenotypes, and also replenish the Kupffer cells in the liver.14, 16, 17, 18 MΦs may undergo polarization into classically activated (M1) or alternatively activated (M2) phenotypes.19, 20 During ...
hepatic IRI [76]. Finally, the human liver is composed of several cell types, including hepatocytes, endothelial cells, Kupffer cells and other immune cell types, bile duct cells, and epithelial progenitor cells; however, the cellular composition and contribution of each cell type during ALI is ...
Hepatic macrophages, also known as Kupffer cells, contribute to hepatic inflammation and lipid accumulation, leading to non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). CSF1R inhibition has been shown to attenuate hepatic inflammation and improve liver function in ...
functions of the liver. And therefore, the same cells in the lungs cannot perform the function of liver cells. Thus the cell differentiation process is vital to maintain the functions of different systems in order and also increase the accuracy and the efficiency of the cellular metabolic ...
T Cells | Definition, Types & Function from Chapter 17 / Lesson 9 32K Understand more about T lymphocytes and their various types. Learn about apoptosis, how T cells work, and discuss the production and maturation of T cells. Related to this ...
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Finally, the human liver is composed of several cell types, including hepatocytes, endothelial cells, Kupffer cells and other immune cell types, bile duct cells, and epithelial progenitor cells; however, the cellular composition and contribution of each cell type during ALI is poorly understood and...