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Here we asked whether the high cellular plasticity of TNBC can be reversed by increasing endogenous ERα expression leading to cell differentiation. As enhanced expression of ERα mRNA and protein is normally associated with DNA demethylation, we investigated mechanisms inducing ERα that are independen...
The four nucleotides that comprise DNA are adenine (A), thymine (T), guanine (G), and cytosine (C). These nucleotides always form Watson and Crick pairs in the same configuration, A-T and C-G and when a number of these pairs come together they form the double...
Within the human population, there are a num- ber of MHC haplotypes called conserved extended haplotypes (CEHs), which exhibit distinctively long stretches of nearly identical sequences where recombination events appear to be unusually low or absent over megabases of DNA7,8. It has been ...
Cell differentiation is a process where stem cells will transform into a specific cell type with a specific function, and will typically remain that cell type for the length of its life.Answer and Explanation: All cells contain the same DNA in their nuclei. However, the main factor tha...
Carbohydrates act as coenzymes for the production of cellular energy, as well as it serves as a structural component of nucleic acid molecules such as DNA (Deoxyribose) and RNA (Ribose). The derivatives of saccharides, as well as themselves, have regulatory functions in the immune system as ...
DNA/RNA recognitionFluorescenceInduced circular dichroismChiral recognitionMolecular modelling•Novel dyes emit fluorescence only for poly rA even at high excess of all other ss-RNA.•Fluorescence response for AT-DNA is 8 times stronger than for GC-DNA.•Florescence induced by ds-RNA is 20% ...
ratio of 1.6 to 1.9 confirmed that the final preparation of total RNA was free of DNA and proteins. First strand cDNA synthesis for RT-PCR To obtain the cDNA, 5 μg RNA was denatured at 70°C for 10 min and then reverse transcribed in the presence of 25 ng/μl random primer (...
Although environmental changes and evolution of life are potentially recorded via microbial carbonates, including laminated stromatolites and clotted thrombolites, factors controlling their fabric are still a matter of controversy. Herein, we report that
In the Red Sea, two neighboring deep-sea brine pools, Atlantis II and Discovery, have been studied extensively and the results have shown that the temperature and concentrations of metal and methane in Atlantis II have increased over the past decades. Therefore, we investigated changes in the mi...