Thepoint mutationis one of the most common mutations, and it occurs in any part of genome. So there are differenteffects on the behavior and reproduction of a protein, and thisdependson where the mutation occurs in the amino acid sequence of the protein.1).If the mutation occurs in thenon...
Berger R, Faassen H van, Taanman JW, Vries H de, Agsteribbe E (1988) Different types of mutations in the chronic and acute forms of type 1 tyrosinemia (abstract). Pediatr Res 24 :266Berger R, van Faassen H, Taanman JW,de Vries H, Agsteribbe A. Different types of mutations in ...
The TP53 gene, encoding the p53 tumor suppressor protein, is frequently mutated in many types of human cancer1,2. The most common type of TP53 mutations are missense mutations, leading to a single amino acid substitution in an otherwise intact p53 protein. In addition, TP53 nonsense and frames...
Intriguingly, bn116 and bn119 were identified as two different mutations on the same gene, pab-1 , which encodes a poly(A)-binding protein. Therefore, although the bn116 and bn119 mutations cause similar defects in germ cell proliferation, their effects on life span are different. 展开 ...
While mutations and epigenetic changes play a critical role in driving cancer progression, no single mutation renders cells metastatic or distinguishes a local from a metastatic tumor. Instead, metastasis is driven by multiple signaling pathways inside the cell in response to many different cues from ...
The disease cystic fibrosis has now been defined as mutations in a particular gene that codes for a cell membrane protein that functions to pump chloride ions out of the cell. This protein in cystic fibrosis is defective in this function because the amino acid sequence is different from normal...
The actin expression, as an internal control of protein loading, was detected by mouse monoclonal antibody (Santa Cruz). ER Stress Signals on Hepatocytes in Liver Tissue To analyze the ER stress, the expression of GRP78 was performed on the LCM-harvested type I and type II GGHs and HBs-...
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells Breast cancer is a genetically and clinically heterogeneous disease, and the contributions of different target cells and different oncogenic mutations to t... Y Li,B Welm...
Here we show that by introducing mutations on the human protein profilin 1, used here as a test case, the in-cell NMR signals can be recovered. In human cells both specific and non-specific interactions are present, while in bacterial cells only the effect of non-specific interactions is ...
Mutations and, consequently, cancerous cells’ incidents can occur in different human tissues and organs. Breast cancer is the most common malignancy in females; however, it can be successfully treated in ~ 70–80% of patients if diagnosed timely7. Breast cancer or mammary carcinoma is init...