In this paper we provide a systematic catalog of the possible scenarios of binding to more than 80,000 ER alpha transcription factor binding sites based on the mechanism of ER alpha binding to DNA (upon both vehicle and estradiol (E2) treatment). A key feature of the estrogen-driven genetic...
infections are parasites (tiny bugs) that live inside and/or outside of the body. Scabies, pubic lice, and certain types of vaginitis can be cured with prescriptions or over-the-counter medicines while intestinal parasites that present symptoms and trichomoniasis often requires the use of ...
Study on biotinylation strategies for competitive immunoassay of estradiol (E2) was carried out. Two types of competitive enzyme immunoassay (EIA) with Biotin-Avidin amplification system were established and optimized.The E2-Biotin conjugate was used as a tracer in one assay, and biotinylated antibody...
Supplementary FigS2b). It was found that after 30 min, and after 1 h of incubation at a concentration of 10 µg/ml, the stimulation of the promoter was the highest (Fig.1). The RecA protein is the main regulator of SOS in the bacterial cell and works ...
In terms of molecular function, DEGs were enriched in transforming growth factor beta binding, insulin-like growth factor binding, estradiol 17 beta dehydrogenase activity and calcium dependent ATPase activity. Also, GO terms associated with vesicle membrane and laminin complex were identified as ...
The serum samples were batched and analyzed in the laboratory in the First Affiliated Hospital of Guangzhou Medical University, and serum FSH, LH, estradiol (E2), TT, prolactin, TG, CHOL, LDL, HDL, fasting plasma glucose, and fasting insulin were measured. The intra-assay and inter-assay ...
Li X, Yuan Z, Liu R, Hassan HM, Yang H, Sun R, Zhang L, Jiang Z (2016) UDCA and CDCA alleviate 17alpha-ethinylestradiol-induced cholestasis through PKA-AMPK pathways in rats. Toxicol Appl Pharmacol 311:12–25. doi:10.1016/j.taap.2016.10.011 Article CAS PubMed Google Scholar Stone...
Estradiol, the major estrogen sex hormone in humans and a widely used medication. Credit: Public Domain A joint study by the University of Oulu and University of Helsinki, Finland, compared the effects of two different types of estrogen in combined contraceptives (COCs) on blood inflammatory mark...
A double signal enhanced surface plasmon resonance (SPR) biosensor system was developed, which involved graphene-based magnetic dispersion solid-phase extraction (MDSPE) and carboxylated graphene oxide (GO-COOH) materials as amplifying elements in order to achieve real-time determinations of estradiol (...
Follicle-stimulating hormone receptor (FSHR), a G protein-coupled receptor that binds to FSH, activates many intracellular signaling pathways, playing an important role in female follicle development and estradiol production. The gene mutation and downregulation of FSHR cause POI by preventing follicle ...