In this paper we formulate and explore a mathematical model to study continuous infusion of a vascular tumour with isolated and combined blood-borne chemotherapies. The mathematical model comprises a system of nonlinear partial differential equations that describe the evolution of the healthy (host) ...
In this paper we formulate and explore a mathematical model to study continuous infusion of a vascular tumour with isolated and combined blood-borne chemotherapies. The mathematical model comprises a system of nonlinear partial differential equations that describe the evolution of the healthy (host)...
We report that eATP increased iATP levels and promoted drug resistance to various tyrosine kinase inhibitors (TKIs) and chemo-drugs in human cancer cell lines of five cancer types. In A549 lung cancer cells, the resistance was downregulated by macropinocytosis inhibition or siRNA knockdown of PAK1...
Kusari S, Sezgin S, Nigutova K, Cellarova E, Spiteller M (2015) Spatial chemo-profiling of hypericin and related phytochemicals in Hypericum species using MALDI-HRMS imaging. Anal Bioanal Chem. https://doi.org/10.1007/s00216-015-8682-6 Article Google Scholar Kuta DD, Tripathi L (2005) ...
promoted high anticancer effects of chemo-SDT in target cancer cells. Briefly, engineered exosomes combining with US irradiation not only show high biocompatibility, long blood retention, and precise tumor targeting, but also achieve drug release controllably and no adjacent normal tissue damage. These...
Flavonoids like tangeretin and genistein showed important chemosensitization of drug-resistant ovarian cancer cells to different agents like cisplatin and taxane drugs, as well as gemcitabine and topotecan. These natural compounds increased cell death by downregulating the PI3K/Akt pathway [75]. PI3K/...
MLLGA presented increased DOT1L phosphorylation, HOXA gene expression, CDK1 activity and phosphorylation of proteins involved in RNA metabolism, replication and DNA damage when compared to MLLGB and no KMT2A rearranged samples. MLLGA was particularly sensitive to 15 compounds including genotoxic drugs ...
We proposed a systematic approach which effectively integrated data mining, chemogenomic, pharmaco- logical and statistical methods to identify molecular targets of active compounds. First of all, a text mining for all target proteins was carried out in HIT (Herbal Ingredients' Targets database, ...
Identification of malignant epithelial cells and specific chemotherapy drugs in different pathological types of EC Tumor cells constitute the primary component of tumor mass and are pivotal in facilitating distant metastasis. In this study, we investigated the heterogeneity of malignant epithelial cells by...
First-line cancer treatments include radiation therapy and chemotherapy [88]. One of the most challenging aspects of cancer therapy is resistance to treatment [89]. In some studies, flavonoids were used as co-treatment with chemo/radiotherapies to reduce resistance or increase sensitization (as a ...