Study on the Correlation between Serum Lipid Level and Severity of Parkinson's Disease Objective To observe whether there are differences in blood lipid levels among patients with Parkinson's disease with different h-y stages. Methods The sel... XU Ze-Heng,XL Yang,DO Neurology - 《World ...
This study investigated gray matter (GM) and white matter (WM) damage in 89 patients at different clinical stages of Parkinson's disease (PD) (17 early, 46 mild, 14 moderate, and 12 severe) to differentiate the trajectories of tissue injury in this condition. PD patients had a very little...
Suttrup I, Suttrup J, Suntrup-Krueger S, et al. Esophageal dys- function in different stages of Parkinson's disease. Neurogastroen- terol Motil 2017;29. doi: 10.1111/nmo.12915. Epub 2016 Jul 31.Suttrup I, Suttrup J, Suntrup-Krueger S, Siemer ML, Bauer J, Hamacher C, et al. ...
The speed and pen-pressure while sketching a spiral are lower among Parkinson's disease (PD) patients with higher severity of the disease. However, the correlation between these features and the severity level (SL) of PD has been reported to be 0.4. There is a need for identifying parameters...
Levodopa is the principal agent in the treatment of Parkinson's disease (PD). Unfortunately the therapeutic benefits are optimal only in the early stages of the disease, with long-term use associated with motor complications such as levodopa-induced dyskinesia (LID). Risk factors associated with ...
The default mode network (DMN) decreases its activity when switching from a resting state to a cognitive task condition, while activity of the network engaged in the given task increases. Visual processing is typically disturbed in Parkinson's disease dementia (PDD). Using functional MRI, we stud...
Parkinson's Disease (PD) is associated with the loss of dopaminergic neurons in the substantia nigra causing classic motor symptoms such as bradykinesia, resting tremor and stiffness, in addition to non-motor symptoms such as respiratory disorders. The aim of this paper is to improve our knowledge...
Our work demonstrates structural and pathological differences between α-syn fibrils derived from PD patients at a spectrum of clinical stages, which suggests potential conformational transition of α-syn fibrils during the progression of PD. 展开 关键词: Parkinson’s disease conformational change cryo...
Parkinson's disease (PD) pathology may damage emotion circuit and cause depression. We investigated whether the neural basis of depressive symptoms varies at different PD stages. Seventy-six healthy controls (HC) and 98 PD patients (divided into early and middle stage groups) underwent brain magnet...
As there are no definite diagnostic tests or reliable biomarkers for Parkinson disease (PD), its diagnosis still relies on the presence of a combination of cardinal motor features, along with the exclusion of other causes of Parkinsonism and the presence of some of supportive features. To date,...