In this chapter, we give an overview of metrics that are useful to evaluate designs for determining if a new drug is efficacious at each of the three premarketing clinical development stages. The three stages are to determine if the new drug exhibits a positive proof of concept, to explore ...
摘要: In this chapter, we give an overview of metrics that are useful to evaluate designs for determining if a new drug is efficacious at each of the three premarketing clinical development stages. The threDOI: 10.1007/978-3-319-46076-5_6 年份: 2017 ...
Several other anti- EGFR antibodies such as zalutumumab and neci- tumumab are also in various stages of development. Cetuximab is a mouse-human chimeric IgG1 with high affinity (Kd ~200 pM) (Goldstein et al., 1995) and has been approved for the treatment of metastatic colorectal cancer ...
Characterization of protein transacetylase from human placenta as a signaling molecule calreticulin using polyphenolic peracetates as the acetyl group donors Our earlier investigations identified acetoxy drug: protein transacetylase (TAase), a unique enzyme in the endoplasmic reticulum (ER) catalyzing the...
This article provides a novel approach to classify the different stages of T1DM, indicating new windows for therapeutic intervention. Article CAS PubMed PubMed Central Google Scholar Greenbaum, C. J. et al. Strength in numbers: opportunities for enhancing the development of effective treatments for...
Recent biomarker research has improved the identification of individuals with very early stages of Alzheimer's disease (AD) and has demonstrated that bioma... SB Hendrix - 《Alzheimers Research & Therapy》 被引量: 38发表: 2012年 Clinical utility of neuroprotective agents in neurodegenerative diseases...
as oncology, hormones, biologics, topical, nasals, peptides, depot injection, inhalers, vaccines and transferral patches. At present, all these products are under different stages of their development and very soon these products would be launched from the first quarter of 2019-20 financial year...
Apelin and apelin receptor at different stages of corpus luteum development and effect of apelin on progesterone secretion and 3β-hydroxysteroid dehydrogenase ... M Ró?Ycka,P Kurowska,M Grzesiak,... - 《Animal Reproduction Science》 被引量: 7发表: 2018年 Hormonal dependent expression of apelin...
S. mansoniis a fascinating parasite; it has a tegument with an intriguing structure and it also has a unique biology throughout the life cycle stages. Understanding the body structure and the biology of this worm is a challenging mission as it will help in the identification of new drug targ...
Starting in the mid-1970s, the industry started outsourcing the discovery of new drug targets and then the early stages of drug development. "When you compare the number of drugs that were approved to their R&D costs," Kinch said, "you see that the cost per drug was going through the ro...