Diagram of different routes for subretinal injections.Qi, YanDai, XufengZhang, HuaHe, YingZhang, YangyangHan, JuanjuanZhu, PingZhang, YuxinZheng, QinxiangLi, Xia
A retrospective review of phytonadione use in reversing excessive anticoagulation was performed in 3 institutions. The effectiveness of low-dose ( or =2.0 and 5.0) in 2 of 8 patients in the LDIV, 0 of 9 in the HDIV, 3 of 10 in the SC, and 1 of 6 in the PO groups. Overcorrection...
The biological fate of synthetic water-soluble polymers administered to mice by injection at different sites is described. After intraperitoneal (ip), subcutaneous (sc), and intramuscular (im) injections of 125l-labeled poly(vinyl alcohol) (PVA) and poly(ethylene glycol) (PEG) with various molecu...
Cows were organized into 2 groups based on milk production (<20 or >30 kg of milk/d). All cattle were administered 2 doses of 1.1 mg of FLU/kg at 12-h intervals by intravenous, intramuscular, and subcutaneous injections. The washout period between routes of administration was 7 d. ...
Impacts of different methylprednisolone administration routes in patients with sudden hearing loss or Meniere’s disease Dan Chen, Zhipeng Li, Qilin Zhou, Yubin Chen, Luoying Yang, Jingqian Tan, Xiangli Zeng, Peng Li Background: Evidence suggests that glucocorticoids are important in the treatment ...
bovis strain was well tolerated and no progressive TB was produced in different animal models, such as Guinea pigs, cows, horses, hamsters, mice, rabbits, dogs, chicken, and non-human primates, after administration at various doses and through different routes [ 30 ]. The safety and efficacy...
Intranasal administration has been shown to have an advantage over other parenteral systemic administration routes for the delivery of biological macro- molecules such as peptides5,6, proteins7–9, oligonucleotides10 and gene vectors11 to the brain. We have previously described how labeled proteins ...
revealed increased concentrations of antigen-specific cytokines, compared with analysis of pooled MLNs (Fig. 1a). These responses were only observed in the sMLNs or cMLNs draining the respective injection sites (Fig. 1c). Thus, intestinalS. mansoniegg injections can be used as an experimental...
Parenteral routes of drug administration are often selected to optimize actual dose of drug delivered, assure high bioavailability, bypass first-pass metabolism or harsh gastrointestinal environments, as well as maximize the speed of onset. Intramuscular (IM) delivery can be preferred to ...
6H sttmulatlonoccured In a dose-respons~vemanner afterSC and after IN routes oi adrn~n~stration.Althougthhe degree of GH st~mulation.lnterms of GH peak and GH Integrated concentrallon.was varlable among subjects,the greatest amounl of stimulation occured wlth the h~ghestdoses.Ifmaxlmal...