2. Major depressive disorder (MDD) has become pervasive. A major contributor to the years lost to disability worldwide, in terms of the burden of disease, by 2030 MDD is predicted to become the largest contributor3. Adding to this problem...
R. Inhaling medicines: delivering drugs to the body through the lungs. Nat Rev Drug Discov 6, 67–74 (2007). 2. Lochhead, J. J. & Thorne, R. G. Intranasal delivery of biologics to the central nervous system. Adv Drug Deliv Rev 64, 614–628 (2012). 3. Lochhead, J. & Thorne,...
to five drugs (olanzapine and fluoxetine combination, quetiapine, lurasidone, cariprazine, and lumateperone), and only one of these drugs (quetiapine) is licensed by the European Medicines Agency (EMA) in Europe for the treatment of bipolar depression [7,8]. Lurasidone and cariprazine have been...
Propolis is known for its immunomodulatory properties. We investigated the effects of three recently developed propolis extract formulations: polar propolis fraction (PPF), soluble propolis dry extract (PSDE), and microencapsulated propolis extract (MPE), and some of their components, on pro- and ant...
Using ILs as matrix media, the volatile components in food and herbal medicines can be comprehensively and scientifically evaluated. This study aims to establish an IL-based HS-GC-MS method to analyze and identify volatile components in leaf, pericarp, and seed of Clausena lansium from different ...