Mutations and, consequently, cancerous cells’ incidents can occur in different human tissues and organs. Breast cancer is the most common malignancy in females; however, it can be successfully treated in ~ 70–80% of patients if diagnosed timely7. Breast cancer or mammary carcinoma is init...
The chromosome mutations and the number of sister chromatid exchanges induced by different kinds of immunosuppressive treatment were investigated in children and adults with certain types of renal diseases. The aim of the study was to find among the treatment schedules those promising good therapeutic ...
A simple blood test detects eight different kinds of cancer by looking for genetic mutations and proteins linked with tumours.doi:10.1038/d41586-018-00926-5Heidi LedfordNatureSimple Blood Test Detects Eight Different Kinds of Cancer, Nature. 18 January 2018. Available online: https://www.nature....
Over time, a particular gene will be copied and transmitted to offspring and may accumulate mutations in the process. Third, evolutionary biologists focus on history, mutation, variability, and gene duplication. Over time in different species, as mutation and natural selection have their effects, ...
On-chip non-contact mechanical cell stimulation - quantification of SKOV-3 alignment to suspended microstructures Although the accumulation of random genetic mutations has been traditionally viewed as the main cause of cancer progression, altered mechanobiological prof... Sevgi Onal,Maan M. Alkaisi,Volk...
Autophagy is a major catabolic pathway capable of degrading all kinds of intracellular material including proteins,lipids, polysaccharides nucleic acids . During its main pathway, phagophores capture cytosol and organelles to formautophagosomes, followed by the fusion of these double-membrane vesicles wit...
In Arabidopsis, mutations in FIDDLEHEAD and CER genes have been shown to disrupt VLCFA biosynthesis, and thus affect pollen-stigma interaction, indicating important roles for VLCFAs in reproductive processes [45, 47–49]. We also identified a number of genes involved in phospholipid synthesis in ...
Common alterations of cell cycle control (i.e. TP53, CDKN2A/RB1 mutations), oxidative stress (i.e. NFE2L2/KEAP1/CUL3), cell survival (i.e. genes in the Pi3K/Akt pathway), cell differentiation (i.e. SOX2/TP63/NOTCH1) and epigenetic (i.e. KMT2C, KMT2D) pathways are also ...
Here we show that by introducing mutations on the human protein profilin 1, used here as a test case, the in-cell NMR signals can be recovered. In human cells both specific and non-specific interactions are present, while in bacterial cells only the effect of non-specific interactions is ...
Language does evolve, but as with evolution in nature, there are far more mutations that do not survive, because they are not as effective as others. We’ve all (at least, those of us who have lived a few decades) seen words and usage come and go in our language. I’ll wager that...