Glutaredoxin 2 overexpression protected human lens epithelial cells against H2O2-induced apoptosis while glutaredoxin 2 knockdown showed the opposite effect [66]. Expression profiles of enzymes known to catalyze reactions influencing the state and metabolism of antioxidant enzymes (thioredoxin reductases) and...
9. Mutations in the myocilin C-terminal olfactomedin domain (OLF, Fig.1B) are causative for ocular hypertension and an accelerated timeline for the blindness disease glaucoma10,11. Unlike a typical client,
The exosomes decorated with specific targeted molecules, including peptides, can achieve more precise therapeutic cargo delivery. The miR-HER2 (human epidermal growth factor receptor 2)-loaded exosomes coated with ligands, which enables them to adhere to HER2 on the surface of human laryngeal carcinom...
All of these aspects suggest that there was a deliberate human choice to incorporate the larger cattle into herds, and they were preferred over the smaller stock. The process described above is logical if human choice is considered to have been the main driving force behind cattle body size cha...
further progress into understanding the drivers of microbial evolution in the gut of different animal hosts requires us to move beyond focusing on this particular species and to look at evolution in real time across a broader range of species. This is crucial for determining the main factors gover...
摘要原文 Background. The brain may reorganize to optimize stroke recovery. Yet relatively little is known about neural correlates of training-facilitated recovery, particularly after loss of body sensations. Objective. Our aim was to characterize changes in brain activation following clinically effective ...
If a human has two copies of the gene for hemoglobin S, then with high probability the individual is likely to develop a broad constellation of symptoms that constitute sickle cell disease. Complications of swelled heart, ulcerated skin, spleen failure, and shortness of breath are all associated...
15. cDCs expressing high amounts of CD103 and relatively low amounts of CD11b are a homogeneous population developmentally dependent on the transcription factor, BATF3, and referred to as CD103+cDCs, or simply “DC1”16,17. Human cDC1 can be identified by their display of CD141 on their...
This commonly used adenoviral vector is human serotype 5 (AdHu5), a common-cold virus circulating in humans with a seropositive rate of 40–60%22,23. To circumvent the downside of pre-existing immunity to AdHu5, rare serotypes of human adenovirus or those derived from other species, such ...
These personalities are often considered by the people of the human resources department before appointing a person is to a particular post. 44.Why are employees advised to take an ability test and personality test A.To make them realize the power of the company. B.To make them make more mo...