Alleles and Aging: The Effects of Different Forms of Genes on Aging and Longevity.Examines the relation or contribution of alleles to aging. Views on aging and its mechanisms; Genetic components of longevity; Implications of alleles for aging.Schlessinger...
Pop music is the name for different forms of popular, commercial (商业) music. It had its beginning in the USA and spread throughout the whole world during the 1950s and 1960s. It is widely liked by the young people. The best known early form of pop music was “rock’ n’ roll”;...
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The brown module was identified as the most relevant module to the above immune cells by WGCNA. We identified two major nonparoxysmal AF subtypes by consensus clustering analysis and their enriched biological functions by Metascape. The hub genes are TYROBP, PTPRC, ITGB2, SPI1, PLEK, and CSF...
The Different Forms of DNA B-form DNA B-DNA is the Watson–Crick form of the double helix that most people are familiar with. They proposed two strands of DNA — each in a right‑hand helix — wound around the same axis. The two strands are held together by H‑bonding between the...
then models should have these components. It will also be necessary to compare findings between models of different mutant genes implicated in PD to identify their biological “intersection”. While the magnitude of locus associations nominated through GWAS are too small and too pleiotropic to drive ...
This is partly because genes are under multiple evolutionary constraints, and partly because the concept of a gene has both structural and functional aspects that do not always align perfectly. A modern description of a gene must consider not only its structure, as a length of DNA, but also ...
Differentially expressed genes (DEGs) were screened by the limma package. Cluster Profiler and GO plot packages were used for enrichment analysis to verify the results of MR analysis. Results Two-sample MR analysis showed a causal relationship between obesity and childhood allergy (age < 16),...
As an important transcription factor, p53 is responsible for regulating the expression of genes related to proliferation, DNA repair, senescence and cell death [62, 63]. p53 also interacts with autophagy via multiple pathways in the context of tumor. Autophagy suppressed p53 by reducing oxidative ...
Incidence of premature ovarian failure (POF) is higher with the increase of the pace of life. The etiology of POF is very complex, which is closely related to genes, immune diseases, drugs, surgery, and psychological factors. Ideal animal models and evaluation indexes are essential for drug de...