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such as Aβ40/42, AβN3pEand AβpSer8[4,24,38,44,57,61,75]. Aβ aggregation, thereby, starts with the accumulation of amyloid fibrils that are only detectable with antibodies detecting non-modified forms, followed by the presence of AβN3pEand finally by AβpSer8, indicating a proce...
By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your perso...
By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your perso...
1.67 times than those of EMs. Further ROC analysis revealed that individuals under once daily in the morning (q.m.) dosing regimen exhibited a more effective response to atomoxetine when their levels were ≥ 268 ng/mL (AUC = 0.710,P < 0.001). In addition, CYP2D6 IMs receiving...
infantile form, and with a residual gaa activity ranging 3-35% of control values in the late onset forms. these data indicate a clear cut relationship between enzyme activity levels and severity of phenotype in the infantile form whereas, in late-onset patients, there is no definite correlation...
Consent for publication Not applicable. Competing interests The authors declare no competing interests. Additional information Responsible Editor: Christian Gagnon Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. ...
EMS: Emergency medical services ERR: Excess relative risk Gpa: Gigapascal (109Pascal) Gy: Gray HAZMAT: Hazardous materials HYSPLIT: Hybrid Single-Particle Lagrangian Integrated Trajectory Model IED: Improvised explosive device IMBA: Integrated Modules for Bioassay Analysis ...
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This study was approved by the ethical committee of the Hospital Universitario La Paz (CEIm PI-446), and informed consent was obtained from all patients and/or their parents. In addition to the SOGRI patients, a review of all previously reported patients in the scientific literature was made...