M. A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3. Oncogene 18, 1643-8 (1999).Dennler S,Huet S,Gauthier J M.A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3. Oncegene ....
treatment regimens, improving chronic pain management by rebalancing neuroimmune feedback. Given the significance of interactions between nerves and immune cells in the generation and maintenance of neuropathic pain, this review focuses on sex differences and possible links with persistent autoimmune activity...
TGF-β signaling is initiated upon TGF-β ligand interaction with type II and type I transmembrane serine/threonine kinase receptors on the cell surface which induces oligomerization of the receptor kinases and phosphorylation of the cytoplasmic signaling molecules Smad2 and Smad3 for the TGF-β/...
Smad proteins, which convey signals from TGF-β receptors to the nucleus, have intermediate linker regions between conserved Mad homology (MH) 1 and MH2 domains. TGF-β type I receptor and pro-inflammatory cytokine-activated kinases differentially phosphorylate Smad2 and Smad3 to create phospho...
Direct nuclear targeting of CLIC4 enhances TGF- signalling and removes the requirement for Schnurri-2. Nuclear CLIC4 associates with phospho (p)-Smad2 and p-Smad3, protecting them from dephosphorylation by nuclear phosphatases. An intact TGF- signalling pathway is essential for CLIC4-mediated ...
We found that, at the tissue level, HIF-1伪, PDK1, TGF-尾1, Smad2, Smad3, and 伪-SMA were mainly distributed and expressed in tubular epithelial cells but were barely present in the renal mesenchymal fibroblasts of healthy cattle and yak kidneys. Anoptical density analysis showed that in ...
The interaction between IL-1 and IL1R1 causes a conformational change of the receptor that determines its association with the adaptive protein MyD88. MyD88, encoded by the MYD88 gene, is a signal transducer that promotes the subsequent NF-κB-mediated transcription [45]. Our results show ...