Dennler S,Huet S,Gauthier JM.A short amino - acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3. Oncegene . 1999Dennler, S., Huet, S., Gauthier, J. M. (1999) A short amino-acid se- quence in MH1 domain is responsible for functional ...
Moreover, several TFs play known roles in cancers, such as ASCL1 [65, 66], NCOR1 [67], SMAD2 [68], and SMAD4 [68]. However, the interaction between sex and cancer on most TFs remains uncharacterized. Importantly, TFBSs enrichment in sex-amplifiers is not driven by sex-biased ...
treatment regimens, improving chronic pain management by rebalancing neuroimmune feedback. Given the significance of interactions between nerves and immune cells in the generation and maintenance of neuropathic pain, this review focuses on sex differences and possible links with persistent autoimmune activity...
TGF-β signaling is initiated upon TGF-β ligand interaction with type II and type I transmembrane serine/threonine kinase receptors on the cell surface which induces oligomerization of the receptor kinases and phosphorylation of the cytoplasmic signaling molecules Smad2 and Smad3 for the TGF-β/...
Our data also showed that downstream Smad2 and Smad3 activation was greater in female rats. Myostatin is also known as growth differentiation factor (GDF)-8 and is a member of the TGF-β superfamily that negatively regulates muscle mass [46, 47]. Myostatin binding to activin type IIB ...
Direct nuclear targeting of CLIC4 enhances TGF- signalling and removes the requirement for Schnurri-2. Nuclear CLIC4 associates with phospho (p)-Smad2 and p-Smad3, protecting them from dephosphorylation by nuclear phosphatases. An intact TGF- signalling pathway is essential for CLIC4-mediated ...
Our data also showed that downstream Smad2 and Smad3 activation was greater in female rats. Myostatin is also known as growth differentiation factor (GDF)-8 and is a member of the TGF-β superfamily that negatively regulates muscle mass [46, 47]. Myostatin binding to activin type IIB ...
We found that, at the tissue level, HIF-1伪, PDK1, TGF-尾1, Smad2, Smad3, and 伪-SMA were mainly distributed and expressed in tubular epithelial cells but were barely present in the renal mesenchymal fibroblasts of healthy cattle and yak kidneys. Anoptical density analysis showed that in ...
Complex molecular pathways strive to obtain iron homeostasis, characterized by a balance between iron intake from the diet via the duodenal enterocytes, iron usage, and iron recycling via the macrophages from senescent red blood cells, while an iron reserve is predominantly maintained in the hepatocyte...