Dennler S, Huet S, Gauthier JM: A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3. Oncogene. 1999, 18: 1643-1648. 10.1038/sj.onc.1202729.DennlerS, HuetS, GauthierJM. A short amino-acid sequence in MH1 domain is responsible for ...
(G) Total copies per cell of the TGF-β proteins TGFBR1, TGFBR2, SMAD2, SMAD3, and SMAD4 in ex vivo mouse and human microglia ± SEM. (H) Comparison of differentially expressed proteins between ex vivo mouse and human microglia at the protein level (y axis) compared to differentially ...
treatment regimens, improving chronic pain management by rebalancing neuroimmune feedback. Given the significance of interactions between nerves and immune cells in the generation and maintenance of neuropathic pain, this review focuses on sex differences and possible links with persistent autoimmune activity...
Wilkes, M. C., Murphy, S. J., Garamszegi, N. & Leof, E. B. Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3.Mol. Cell. Biol.23, 8878–8889 (2003). ArticleCASPubMedPubMed CentralGoogle Scholar Chan, W. H., Yu, J. S. &...
It has also been shown that SPARC interacts with the TGF-β-receptor complex to modulate phosphorylation of Smad-2 (SMAD2), to affect the activity of JNK (MAPK8), and to increase the expression of c-jun (Jun) [10]. More recently, SPARC has been shown to interact with Stabilin-1 (...
www.nature.com/scientificreports OPEN Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro‑inflammation, fertility and craniosynostosis Benjamin Ng1,2,6, Anissa A. Widjaja1,6, Sivakumar Viswanathan1, Jinrui Dong1, Sonia P. Chothani1, ...
(1999). "A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3." Oncogene 18(8): 1643-1648.Dennler S, Huet S, and Gouthier JM. A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3...
Direct nuclear targeting of CLIC4 enhances TGF- signalling and removes the requirement for Schnurri-2. Nuclear CLIC4 associates with phospho (p)-Smad2 and p-Smad3, protecting them from dephosphorylation by nuclear phosphatases. An intact TGF- signalling pathway is essential for CLIC4-mediated ...
Finally, negative injury signaling hinders the retrograde transport of trophic factors and serves as a negative regulator of neuronal growth, including, for example, via the trans- forming growth factor (TGF)-β/SMAD2/SMAD3 pathway (reviewed in [63]). The consequent outcome of peripheral axonal ...
Differences in gene-expression profiles between individual cells can give rise to distinct cell fate decisions. Yet how localisation on a micropattern impacts initial changes in mRNA, protein, and phosphoprotein abundance remains unclear. To identify the