The rapid development of transcriptional differences between jejunum and ileum reveal that these two intestinal regions make distinct contributions to the intestinal mucosal immune system during the early neonatal period. In addition, transcriptome analysis indicates that the first week after birth is a ...
In situ intestinal perfusion was performed in rat duodenum, jejunum, ileum and colon to measure the influence of P-gp expression on efflux. Inhibition studies of CNV97100 were performed in the presence of verapamil, quinidine, cyclosporin A and p-aminohippuric acid. Absorption/efflux parameters ...
Incorporation of [1-14C]palmitic (16:0) and [1-14C]linoleic (18:2 omega 6) acids into microsomal membranes of proximal (jejunum) and distal (ileum) regions of rat small intestine was investigated, and the lipid composition, including fat... ML Garg,M Keelan,A Wierzbicki,... - 《Canadi...
6. Jejunum 6(4.6) Total 130 Strictures of the intestine were the cause for intestinal obstruction in 94 patients. These were possibly due to ischaemia in 26 patients (with equal numbers found in the jejunum and ileum), tuberculosis in 16 patients (14 in ileum and 2 in jejunum) and precedi...
Lyon and Crane 6 have reported that, in rat jejunum, the maximum Δp.d. resulting from addition of actively transported sugars is independent of sodium concentration when tris [2-amino-2(hydroxymethyl)-1,3-propanediol] is used to replace sodium, but decreases when potassium is used as ...
Isolated segments of rat jejunum and ileum were perfused with UK-343,664 solution and measurements were made as a function of drug concentration for dose dependence and in the presence of CYP3A and P-gp inhibitors. Intestinal permeability and metabolism were measured by total drug disappearance and...
Transport studies of rhodamine 123, a substrate of P-glycoprotein, were performed in everted jejunum and ileum. The level of mdr3 mRNA and P-glycoprotein found in ileum was 6-fold higher than the level found in duodenum. The regional pattern of mdr3 gene expression is established in the ...
The aim of this study was to characterize the influence of gender on P-glycoprotein (P-gp)-mediated drug intestinal transport using two ex-vivo methodological approaches.Methods To study the comparative tissue uptake of ivermectin, intestinal sacs (distal jejunum/ileum) of male and female Wistar ...
Interestingly, female rats displayed significantly higher relative P-gp expression levels ( p <0.05) when compared with male rats in the duodenum (1.24 ± 0.85 vs . 0.36 ± 0.26), jejunum (1.45 ± 0.88 vs . 0.38 ± 0.26) and ileum (0.92 ± 0.43 vs . 0.40 ± 0.18) but not in the ...
The mannitol permeability was higher in the small intestine than in the colon in man, whereas the rat showed a higher permeability in the ileum than in the jejunum and colon. The FITC-dextran 4,400 permeability was higher in all intestinal regions in the rat than in man and the pig. The...