PHENOTYPESGENOTYPESVETERINARY medicineNOSOCOMIAL infectionsMULTIDRUG resistanceS. aureus is one of the most important causes of nosocomial infections, main contagious pathogens that can play a vital and important role in bovine mastitis in veterinary medicine causing high worldwide economic ...
Recent research has identified sex-dependent links between risk taking behaviors, approach-avoidance bias and alcohol intake. However, preclinical studies have typically assessed alcohol drinking using a singular dimension of intake (i.e. drinking level), failing to capture the multidimensional pattern of...
Metformin improves the spatial memory of female, but not male apoE3-TR mice and female apoE4-TR mice while aggravating the cognitive impairment of male apoE4-TR mice. The anxiety-like phenotypes in male apoE4-TR mice are more severe than in male apoE3-TR mice, while metformin ameliorates ...
GWAS sufficiently powered to allow stratification by sex has demonstrated the heterogeneity of genetic effects between males and females in association with complex traits [30]. Genetic variants may indeed show sex bias in their regulation of gene expression, supported by identified autosomal sex...
Ovariectomized ApoE−/−:Ins2+/Akita mice presented chronic hyperglycemia, and atherosclerosis appeared to be advanced. We have characterized the distinctive sex-specific phenotypes exhibited by the ApoE−/−:Ins2+/Akita mouse model and present evidence for the action of sex hormones on ...
Although the genetic differences (between sexes, between hybrids and parents) are crucial, the lowered fitness of hybrid genotypes must be related to its physiological specifity. Explaining of this specifity is important to understand why some genotypes perform worse than others. Unfortunately, most of...
The DRAGEN uses an algorithm that can reduce errors in actual data where correlations between reads are observed [22]. Therefore, DRAGEN genotypes have lower distribution of GQ than GATK. As such, we tried to adjust the threshold of de novo probability to rescue false-negative calls whose ...
chromosome-dependent immune phenotypes are influenced by the gut microbiome. Previously, our lab demonstrated that the immunomodulatory compound propanil (3,4-dichloropropionanalide) enhances immune responses to heat-killedStreptococcus pneumoniae(HKSP) immunization in an XX sex chromosome complement-dependent...
For example, MAGEL2 KO mice showed increased anxiety in novel environments and altered social interaction phenotypes [4] as well as deficits in social memory [5]. In general, alterations in MAGEL2 appear to be associated with behavioral changes across species, which may reflect abnormal production...
Development of WT and Fmr1 KO male and female ERP phenotypes Auditory cortex – WT mice ERP P1 amplitudes were not impacted by age or sex in the AC. However, both N1 and P2 amplitudes were affected by age (N1 – main effect of age: p = 0.0188; P2 – main effect of age: p...