Finding that differences between individuals (traits, whether assessed quantitatively as a dimension or qualitatively as a diagnosis) are significantly heritable is so ubiquitous for behavioural traits that it has been enshrined as the first law of behavioural genetics.7Although the pervasiveness of this ...
Among the non-MHC genes, some of the risk alleles are shared between different AIDs, but may not be common to all AIDs. For example, genetic polymorphisms in the Protein Tyrosine Phosphatase-22 (PTPN22) gene have reproducibly shown to have association with systemic lupus erythematosus (SLE), ...
Meiotic recombination differs between males and females; however, when and how these differences are established is unknown. Here we identify extensive sex differences at the initiation of recombination by mapping hotspots of meiotic DNA double-strand breaks in male and female mice. Contrary to past ...
Using electronic health records to drive discovery in disease genomics. If genomic studies are to be a clinically relevant and timely reflection of the relationship between genetics and health status--whether for common or rare... Kohane,S Isaac - 《Nature Reviews Genetics》 被引量: 389发表: 20...
1). These differences in gene expression and hormone levels between the sexes are found to contribute to sex-differences in stress response, including a general female advantage in cellular stress resistance. 3. Sex chromosome gene dosage and X-linked gene mutations Sex chromosome gene dosage has ...
Although a great deal is now known about the genetics of reproductive isolation, we are only beginning to understand the genetic basis of ordinary phenotypic differences between species. I review what is known about the number of genes involved in such differences, as well as about the role of...
Several observations support the hypothesis that differences in synaptic and regional cerebral plasticity between the sexes account for the high ratio of males to females in autism. First, males are more susceptible than females to perturbations in genes
Protein binding to all three motifs was constitutive, and no differences were observed between induced and non-induced cultures. Mutation of either the CC... C Peterbauer,K Brunner,R Mach,... - 《Molecular Genetics & Genomics Mgg》 被引量: 54发表: 2002年 ...
and its ranking of individuals does not differ substantially depending on the test battery. Among the sources of between-individual variance that are extractable from a set of cognitive test scores, it tends to be thegfactor that leads the way in being associated with life outcomes, and with ...
separation and map distances between recessive mutations and their linked centromeres25. Based on these analyses, the sex determining locus was predicted to occur near the end of an undefined chromosome25and later estimated to be 59.1 cM distal to the centromere (essentially, freely recombining)...