E. Similarities and differences in patterns of germline mutation between mice and humans.Nat. Commun. 10, 4053 (2019). Article Google Scholar Harland, C. et al. Frequency of mosaicism points towards mutation-p
Among the non-MHC genes, some of the risk alleles are shared between different AIDs, but may not be common to all AIDs. For example, genetic polymorphisms in the Protein Tyrosine Phosphatase-22 (PTPN22) gene have reproducibly shown to have association with systemic lupus erythematosus (SLE), ...
Natural selection contributed to immunological differences between hunter-gatherers and agriculturalistsEvolutionEvolutionary biologyFunctional genomicsGeneticsThe shift from a hunter-gatherer to an agricultural mode of subsistence is believed to have been associated with profound changes in the burden and ...
Interestingly, the differences in expression are particularly profound between (early) developmental and adult tissues, which in itself might explain why this previously has been overlooked, since apparently there are only a limited number of mitochondrial studies involving many developmental and adult ...
By means of a novel Bayesian approach, statistical support for a distinct multimodal rather than a uniform allele size distribution was detected in seven out of eight MSRs, with evidence for equidistant intervals between the modes. The multimodal distributions with evidence for equidistant intervals, ...
The goals of this chapter are: (1) to highlight differences in recombination rates between the sexes, (2) describe why we might expect these differences, and (3) explore how sex difference in recombination can be used to improve resolution in QTL mapping....
Our goals were to determine gene-expression differences between these two populations, to identify what biological processes or pathways are enriched in the differentially expressed genes, and to evaluate the contribution of local and distant genetic variation to population differences in gene expression....
There were significant differences in the sets of promoters bearing bivalent marks in the different cell types and few consistent differences between fNSCs and BTSCs. Conclusions Overall, our ???core set??? data establishes sets of potential therapeutic targets, but the diversity in sets of sites...
What is the difference between manual sequencing and automated sequencing in genomics? Next Generation DNA Sequencing methods have dominated the study of microbial diversity in the last 12 years. Compare and contrast the Sanger vs. the Illumina approach ...
Several observations support the hypothesis that differences in synaptic and regional cerebral plasticity between the sexes account for the high ratio of males to females in autism. First, males are more susceptible than females to perturbations in genes