This keynote chapter provides an overview of research into the relationship between health and gender/sex. Since health has multiple dimensions, several measures are needed to capture variations by gender and the use of multiple measures can help us better understand the underlying explanations for ge...
Therefore, using the orthotopic tongue cancer xenograft model in mice, we performed bulk-RNA sequencing of isolated tongue-innervated sensory neurons from males and females, to identify changes in genes, biological processes and molecular function between sexes under normal and tumor-bearing conditions....
amphibians have undergone numerous evolutionary transitions between XY and ZW-type mechanisms and may possess morphologically indistinguishable (homomorphic) sex chromosomes, like those of the axolotl10,11,12,13. Homomorphic sex chromosomes are not altogether rare among animals, with ...
Conclusion The present study demonstrates that the structural organization of Y chromosomes differs between crossbred and Indicine bulls which are reproductively healthy as observed from analysis of semen attributes. The absolute copy numbers of SRY and TSPY genes in unit mass of genomic DNA of ...
DTH responses in XX and XY FCG females showed no role for almost all genes expressed on sex chromosomes. After then filtering-out genes differentially expressed between XX and XY females, only one gene was sexually differentially expressed in wildtype mice, glycosylation-dependent cell adhesion ...
In female mammals, the dosage difference in X-linked genes between XX females and XY males is compensated for by inactivating one of the two X chromosomes during early development. Since the discovery of the X inactive-specific transcript (XIS I) gene in humans and its subsequent isolation of...
X-chromosomal genes contribute to sex differences, in particular during early development, when both X chromosomes are active in females. Double X-dosage shifts female pluripotent cells towards the naive stem cell state by increasing pluripotency factor expression, inhibiting the differentiation-promoting ...
Species with sex chromosomes have a different gene dosage between the sexes. For example, human and Drosophila females have two copies of each X chromosome gene, whereas males of each species have only one copy. These species exhibit dosage compensation mechanisms to equalize gene expression levels...
Conclusion:Thepresentstudydemonstratesthatthestructura1organizationofYchromosomesdifiersbetweencrossbred andfndicinebullswhicharereproductivelyhealthyasobservedflr。manalysisofsemenattrDutes.]-heabsolutecoPYnumbers ofSRYandTSPYgenesinunitmassofgenomicDNAofcrossbredbullsaresignificantlyhigherthanIndicinebulls.Noalteration ...
Sex differences in immune responses change throughout life and are influenced by both the age and reproductive status of an individual. Sex chromosome genes and sex hormones, including oestrogens, progesterone and androgens, contribute to the differential regulation of immune responses between the sexes...