Kobayashi, D., Kawabata, S., Sugibayashi, K., Morimoto, Y., Kimura, M. (1996) In vitro=in vivo difference in enhanced skin permeation of nicardipine hydrochloride by the 1- methanol-ethanol system. Skin Pharmacol. 9: 130 ± 136
The in vitro/in vivo difference in enhanced skin permeation of nicardipine hydrochloride (NC) by simultaneous use of 1-menthol and ethanol (MEW system, 1-menthol:ethanol:water = 5:40:55) was investigated in hairless rats. First, the cutaneous blood flow clearance (clearance from skin to blood...
In this publication we have investigated the synthesis of proteins in vitro to detect the proteins with a high metabolic turnover and to compare them with the in vivo protein map. RNA of spermatocytes and round spermatid cell populations, purified by centrifugal elutriation, and total testis was ...
In vitro and in vivo analysis of the interaction between 5.8S rRNA and ARF protein reveal a new difference between murine p19^A^R^F and human p14^A^R^F, ArtículoBoth human and murine ARF proteins have been recently reported to impair rRNA maturation and ribosomes biogenesis through a p53...
Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions With the discussion of principles and accompanying tabulation of literature data concerning the clearance of various drugs, a framework for reasonable semi... RJ Bertz,GR Granneman - 《Clinical Phar...
Di(2-ethylhexyl)phthalate (DEHP), a confirmed promoter of hepatocellular carcinogenesis in mice, was studied for tumor-promoting activity on the skin of SENCAR mice in vivo and on JB6 mouse epidermal cells in vitro. DEHP enhanced transfo... BA Diwan,JM Ward,JM Rice,... - 《Carcinogenesis...
Downregulation of GSTM2 enhances gemcitabine chemosensitivity of pancreatic cancer in vitro and in vivo. Pancreatology. 2021;21(1):115–23. Article CAS PubMed Google Scholar Tibaldi C, Stasi I, Baldini E. Oncogene-addicted non-small-cell lung cancer in women: a narrative review of the ...
Recently, transmural dispersion of repolarization (TDR) has been implicated in the genesis of TdP. Consequently, we compared TdP incidence and TDR between male and female rabbit hearts in order to investigate the mechanism of sex difference in TdP risk in rabbits in vitro.Methods By means of ...
In conclusion, a sex difference in GH responsiveness to was found between young adult men and women. Recent in vivo and in vitro data reveal a similar sex difference in and an enhancing effect of androgens, but not estrogens, on the GH response to . These findings support the theory that ...
Series of studies, including toxicokinetics and metabolism in vivo and in vitro , were carried out to explore the factors responsible for the observed difference in toxicity susceptibility in both ages of mice. The toxicokinetic study demonstrated that the absorption of RTS in new weaned mice was ...