Mitochondrial DNA (mtDNA) is a doublestranded, circular DNA found inside the mitochondria. It encodes proteins and functional RNAs required by mitochondria. But, some proteins, which are encoded by nuclear DNA are imported from the cytosol. Nuclear DNA (nDNA) is composed of several linear ...
The implication is that the ratio of effective population size of nucDNA/mtDNA is much greater than the usually assumed four. The nearly neutral theory of molecular evolution predicts this would lead to a greater difference between rates of evolution....
The implication is that the ratio of effective population size of nucDNA/mtDNA is much greater than the usually assumed four. The nearly neutral theory of molecular evolution predicts this would lead to a greater difference between rates of evolution. 2004 Elsevier Inc. All rights reserved. 展开...
Nevertheless, definitive mtDNA sequence variants in epithelial ovarian carcinogenesis in relation to racial/ethnic and age differences have yet to be established. Given the connection between mitochondria, ROS, and neoplasia, mtDNA from three subtypes of ovarian cancer stages (including the borderline and...
Despite the large divergence among haplogroups there is very low intrahaplogroup variation and no correlated variation in the nuclear genome has been detected. We show that repeatable bioenergetic differences exist between 11d old males harboring II and III mtDNA. Males with III mtDNA showed higher ...