Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α Neeraj Jain & Thirumaran Thanabalu Wiskott-Aldrich Syndrome protein (WASP) integrates cell signaling pathways to the actin cytoskeleton, which play a critical role in T-cell activation and ...
Proteins in whole cells and pseudopodia fractions were individually solubilized, labeled with a highly sensitive fluorescent dye, and separated using two-dimensional difference gel electrophoresis. Among 2508 protein spots observed, 211 had different intensity between whole cells and pseudopodia fractions (...
2. Overview of the Janus Kinase Signal Transducer and Activator of Transcription (JAK-STAT) Signaling Pathway The Janus kinase (JAK)-STAT pathway is a core cancer pathway that transmits a signal from the cell surface to the nucleus through cooperation between JAK kinase and STAT transcription ...