DEFINING MCID In 1989, Jaeschke et al.16 introduced the concept of MCID to determine whether a difference in treatment effect between experi- mental and control participants are judged to be of value to people living with the disorder. They defined the MCID as 'the smallest difference in ...
This means that we want to be 90% confident that we will not detect a difference in systolic blood pressure of more than 2 mmHg between the new drug and existing drug groups, if the two drugs are truly equivalent. Using a standard sample size calculator, we can estimate that we need a...