Topologically associating domains (TADs) are critical structural units in three-dimensional genome organization of mammalian genome. Dynamic reorganizations of TADs between health and disease states are associated with essential genome functions. However
We believe yes!, by joining Engineering, Urban Planning and Architecture together to build Macro-cities. Would reducing pollution drastically while improving living conditions be possible? We believe yes!, by building more efficient geometric Urban environments. Would guarantying structural stability despit...
For case-control studies, knowing differen- tially expressed genes (DEGs) is often of research and clinical interest. Our primary interest also centres on developing a statistical method for differential expression ana- lysis between different groups of individuals, not between cells. The underlying ...
police and shape packets; specify these rules in the service-level agreement (SLA); and decide how many classes of service to provide. If more than one domain is involved, there may be an SLA between them, which determines if the DS field of a packet is ...
Differential networks allow us to better understand the changes in cellular processes that are exhibited in conditions of interest, identifying variations in gene regulation or protein interaction between, for example, cases and controls, or in response to external stimuli. Here we present a novel met...
(A) Volcano plot of differential TF activity between U-CLL (n = 27 biological replicates) and M-CLL (n = 25 biological replicates). Significance threshold (10% FDR) is indicated with a dotted line. TFBS, number of predicted TFBSs. p values are obtained through diffTF using the empirical...
All patients gave written informed consent prior to each therapy cycle and retrospective data analysis was approved by the local ethics committee (approval number: 310/18). 2.2. Radiolabeling and Administration The radiolabeling of PSMA-617 with 177LuCl3 was carried out as has been described in ...
You've got it about right. My block this time came as a result of calling to task the ethics of a struggling college biology student who has refused to release a recorded audio interview that 10 people took two hours of their time to produce, under the impression that the audio would be...
(Fig.2). The dataset must be formatted as an R Seurat object54,55,56and contain cells annotated by cell types and by the two conditions on which the differential analysis will be performed. The package then considers all possible interactions between each cell-type pair, based on the LRIs ...
. Diff isomiRs also provides the relationship between the canonical miRNAs, isomiRs and the miRNA-target interactions. This is the first web-based large-scale repository for browsing differential isomiRs and will facilitate better understanding of the regulatory role of the isomiRs with respect to ...