Y Kimura,A Yamada,Y Takabayashi,T Tsubota,H Kasuga 摘要: Obesity is an increasingly severe socioeconomic health issue worldwide. Rodents with diet-induced obesity (DIO) are widely used as models of obesity. The main aim of this study was to establish a DIO model using Wistar lean (+/+ ...
maybe a bit bigger than I’d guess. Since I know I get a better look at people around me rather than myself, I entered a skinny friend of mines height and weight to see how close the model was to how I see her in real life. It appeared quite a bit bigger than she was for rea...
Aim To establish a new animal model of the human type 2 diabetes mellitus complicated with atherosclerosis and investigate the effects of high fat/high sucrose feeding on glucose and lipid metabolism in guizhou minipigs. Methods Minipigs were fed with high fat/high sucrose diet (HFSD) and the...
Only HOMA remained as an independent predictor in the model after diet, with an increase of 11.4 ng/ml (CI 95%: 1.76 - 21.11) posttreatment visfatin concentrations with each increase of 1 unit HOMA. CONCLUSION: Weight reduction after a 2 months on a hypocaloric diet is not associated with...
Multiple factors of metabolic syndrome have been implicated in the pathogenesis of Alzheimer's disease (AD), including abdominal obesity, insulin resistance, endocrine dysfunction and dyslipidemia. High fat diet, a common experimental model of obesity and metabolic syndrome, has been shown to accelerate...
To investigate the potential role of tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA) in development of adipose tissue, we have used a nutritionally induced obesity model in t-PA (t-PA−/−) and u-PA (u-PA−/−) deficient mice. Five week ol...
Diet-induced obesity in C57BL/6 mice triggers common features of human metabolic syndrome (MetS). The purpose is to assess the suitability of a diet-induced obesity model for investigating non-alcoholic fatty pancreatic disease (NAFPD), fatty liver and insulin resistance. Adult C57BL/6 mice we...
To help overcome these problems, we created a well-defined, representative animal model of the human gut ecosystem by transplanting fresh or frozen adult human fecal microbial communities into germ-free C57BL/6J mice. Culture-independent metagenomic analysis of the temporal, spatial, and ...
* Indicates a credible shift (95% highest posterior density interval of the frequency shift modelled by a Dirichlet multinomial model does not overlap 0). n = 3 CD mice, n = 3 HFHSD mice. f, UMAP coloured by the regional identities of cells in ISCs and goblet cell and ...
Male C57BL/6 mice (male, 20–22 g) had been bought from the Model Animal Research Center of Nanjing University and been bred in a 12:12 h light–dark cycle, water and standard chow diet were provided ad-libitum, the composition of chow diet provided by the manufacturer was showed in ...