A fixed-dose combination diclofenac sodium-misoprostol (ARTHROTEC®, G.D. Searle LLC Division of Pfizer Inc., New York, NY, USA) [31] sequential-release tablet was approved by the US FDA in 1997 for the treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis in patients ...
Two simple, economical, precise and accurate methods for simultaneous determination of Drotaverine Hydrochloride (DRO) and Diclofenac Potassium (DIC) in combined tablet dosage form has been developed. The first method is based on Ratio Spectra Derivative and second method is Area Under Curve (AUC)...