Based on this information, diclofenac sodium was synthesized by Alfred Sallmann and Rudolf Pfister and first introduced by Ciba-Geigy (now Novartis AG, Basel, Switzerland) in 1973 [17,18]. Diclofenac is a phenylacetic acid with an acidity constant of 4, establishing it as a weak acid, and a...
in each case based on the equivalent weight of the non-salt form of Lidocaine and of Diclofenac, for topical use in the local treatment or prevention of pain, wherein the pharmaceutical patch is applied and remains applied to an area of the skin of a patient for an application period of ...