Maximum Dose: 150 mg per day. Comment:Patients should be well hydrated prior to IV administration of this drug in order to reduce the risk of adverse renal reactions. Uses: For the management of mild to moderate acute pain (oral, IV) and moderate to severe pain alone or in combination wi...
Maximum 21 days of treatment unless otherwise directed by a clinician.MigraineOralSingle 50-mg dose (as diclofenac potassium for oral solution mixed with water). Safety and efficacy of administering a second dose not established.Special PopulationsRenal...
Long-term carcinogenicity studies in rats given diclofenac sodium up to 2 mg/kg/day (approximately 0.1 times maximum recommended human dose (MRHD) of diclofenac, 200 mg/day, based on body surface area (BSA) comparison ) have revealed no significant increases in tumor incidence. A 2-year carc...
0.5 to2.0mg/kg per day, the maximum daily amount of 3.0mg/kg, 3 times. the adverse reaction ofgastrointestinal reaction: the most common adverse reactions in 10%, withmedication, mainly for stomach discomfort, acid regurgitation, heartburn,anorexia, nausea, withdrawal or symptomatic treatment can...
Where necessary therapy may be combined with tablets up to a total maximum dose of 150 mg diclofenac per day. Special population: Elderly patients Although the pharmacokinetics of Econac are not impaired to any clinically relevant extent in elderly patients, non-steroidal anti-inflammatory drugs ...
Adult: As an attack treatment in rheumatology: 1 tablet, 3 times daily for 7 days maximum. In maintenance treatment in rheumatology: 1 tablet, 2 times a day. For pain relief: 1 tablet, 2 times a day. In children over 35 kg (approximately 12 to 15 years): 2 to 3 mg per kg and ...
Carcinogenicity studies in mice and rats administered diclofenac sodium as a dietary constituent for 2 years resulted in no significant increases in tumor incidence at doses up to 2 mg/kg/day approximately 0.85 and 1.7 times, respectively, the maximum recommended human topical dose of PENNSAID (bas...
Diclofenac did not affect male or female fertility in rats at doses up to 4 mg/kg/day (approximately 2 times than the maximum human topical dose of VOLTAREN GEL based on bioavailability and BSA comparison). Use In Specific Populations
Given that the mean maximum plasma concentration (Cmax) of diclofenac after a single dose of 50 mg in healthy volunteers is 5 mM (Siu et al, 2000; Juhlin et al, 2004), the dose used in this study is more relevant to the clinical setting. Similarly, the concentration of ibuprofen used ...
(approximately 0.5 times the maximum recommended human dose [MRHD] of diclofenac sodium delayed-release tablets, 200 mg/day, based on body surface area (BSA) comparison), and in rats and rabbits at oral doses up to 10 mg/kg/day (approximately 0.5 and 1 times, respectively, the MRHD ...