Maximum Dose: 150 mg per day. Comment:Patients should be well hydrated prior to IV administration of this drug in order to reduce the risk of adverse renal reactions. Uses: For the management of mild to moderate acute pain (oral, IV) and moderate to severe pain alone or in combination wi...
Long-term carcinogenicity studies in rats given diclofenac sodium up to 2 mg/kg/day (approximately 0.1 times maximum recommended human dose (MRHD) of diclofenac, 200 mg/day, based on body surface area (BSA) comparison ) have revealed no significant increases in tumor incidence. A 2-year carc...
For self-medication, treat no more than 2 body areas at the same time; maximum 16 g of gel applied daily to any single lower extremity joint and 8 g of gel applied daily to any single upper extremity joint. Maximum 21 days of treatment unless otherwise directed by a clinician....
0.5 to2.0mg/kg per day, the maximum daily amount of 3.0mg/kg, 3 times. the adverse reaction ofgastrointestinal reaction: the most common adverse reactions in 10%, withmedication, mainly for stomach discomfort, acid regurgitation, heartburn,anorexia, nausea, withdrawal or symptomatic treatment can...
Usual dosage Adult: As an attack treatment in rheumatology: 1 tablet, 3 times daily for 7 days maximum. In maintenance treatment in rheumatology: 1 tablet, 2 times a day. For pain relief: 1 tablet, 2 times a day. In children over 35 kg (approximately 12 to 15 years): 2 to 3 mg ...
Where necessary therapy may be combined with tablets up to a total maximum dose of 150 mg diclofenac per day. Special population: Elderly patients Although the pharmacokinetics of Econac are not impaired to any clinically relevant extent in elderly patients, non-steroidal anti-inflammatory drugs ...
Carcinogenicity studies in mice and rats administered diclofenac sodium as a dietary constituent for 2 years resulted in no significant increases in tumor incidence at doses up to 2 mg/kg/day approximately 0.85 and 1.7 times, respectively, the maximum recommended human topical dose of PENNSAID (bas...
Diclofenac did not affect male or female fertility in rats at doses up to 4 mg/kg/day (approximately 2 times than the maximum human topical dose of VOLTAREN GEL based on bioavailability and BSA comparison). Use In Specific Populations
Box-plots display the median value, the minimum and maximum value of OA. (A) 10 mM diclofenac increased OA in patients with basal OA less than 4 ng per 200 000 cells (n ¼ 29). (B) No significant increase was observed in patients with basal OA greater than 4 ng per 200 000 ...
the maximum recommended human dose (MRHD) of diclofenac sodium delayed-release tablets, 200 mg/day, despite the presence of maternal and fetal toxicity at these doses[see Data].Based on animal data, prostaglandins have been shown to have an important role in endometrial vascular permeability, bl...