Method and Result: Immunoblotting showed that cordycepin increased Dickkopf-related protein 1 (Dkk1) levels and inhibited 尾-catenin signaling. Atg7 knockdown in ovarian cancer cells significantly inhibited cordycepin-induced apoptosis, whereas 尾-catenin overexpression abolished the effects of cordycepin on...
Dickkopf-related protein 3 is a potential Aβ- associated protein in Alzheimer's disease. J. Neurochem. 134, 1152-1162. doi: 10.1111/jnc.13216Bruggink KA, Kuiperij HB, Gloerich J, Otte-Holler I, Rozemuller AJ, et al. (2015) Dickkopf-related protein 3 is a potential Aβ-associated ...
To investigate the value of Dickkopf-related protein 3 (DKK3) on aerobic glycolysis in pancreatic cancer cells, where DKK3-overexpression is used to determine its effects on CD4+ T cells. The BxPC-3-DKK3 cell line was constructed, and peripheral blood mo
RANKL, a protein expressed on the osteoblast cell membrane, binds to RANK, a receptor located on the osteoclast membrane. RANKL – RANK interaction induces osteoclast differentiation and bone resorption. OPG neutralizes the binding of RANKL to RANK and prevents bone resorption. The Dkk-1 is a ...
Dickkopf related protein 1 (DKK1) has been proposed as the master regulator of joint remodelling. This Wnt signalling pathway inhibitor is involved in osteoblast growth and differentiation. In rheumatoid arthritis, increased DKK1 plasma levels correlate with inflammation and bone erosions. Furthermore,...
Dickkopf-related protein 1 (DKK1), which plays an oncogene role in many cancers, acts as an inhibitor of the Wingless protein (Wnt) signaling pathway. Currently, there is a lack of consensus regarding the role of DKK1 in OSCC or its clinical significance. OBJECTIVE: To examine the role ...
The role of preoperative serum levels for Dickkopf-related protein 1 as a potential marker of tumour invasion in patients with stage II and III colon cancer. Eur. Rev. Med. Pharmacol. Sci. 2014, 18, 1742-1747. [PubMed]Gurluler E, Tumay LV, Guner OS, et al. The role of preoprative...
Dickkopf-related protein 1 (DKK1) is a major inhibitor of Wnt signalling pathway but also plays an important role in bone formation. Its circulating levels appear to correlate significantly with plasma levels of inflammatory factors, fractalkine and IL-6. This study, using a large sample of UK...
AimThe regulation of Wnt-尾-catenin signalling, which is crucial for osteoblast differentiation and for bone resorption, is driven by critical inhibitors such as sclerostin (SOST) and dickkopf-related protein 1 (DKK1). As such, the aim of this study was to evaluate the involvement of SOST ...
The lipid profile, C-reactive protein (CRP) and Dickkopf-related protein 1 (DKK-1) circulating levels were measured for all subjects. For the patients with PsA, (1) the erosive character of the articular disease was assessed by a musculoskeletal ultrasound and (2) the...