DescriptionDiamine oxidase from porcine kidney is a homodimer consisting of 2 equal subunits with a molecular weight of 87 kDa each. Each subunit contains one molecule of pyridoxal phosphate and one atom of copper. The molecular mass of the enzyme is found to be 170 kDa. The enzyme is a gly...
Background: Impaired histamine degradation based on reduced diamine oxidase (DAO) activity has been suggested to cause symptoms mimicking an allergic reaction. Aim: To test whether patients presenting with possible histamine-induced symptoms have a low serum activity of DAO compared to healthy subjects...
histamine; diamine oxidase; molecular mechanisms; clinical application1. Introduction Diamine oxidase (DAO) is a secretory protein located in the cytoplasm of human and mammalian upper intestinal mucosa chromaffin cells and is responsible for catabolizing histamine (mainly extracellular) to stop allergic ...