Despite decades of intensive research, the development of a diagnostic test for major depressive disorder (MDD) had proven to be a formidable and elusive task, with all individual marker-based approaches yielding insufficient sensitivity and specificity for clinical use. In the present work, we ...
The first stage of this study is a case–control study, aims to explore the risk factors for developing MDD and then define the subtypes of MDD using 1200 MDD patients and 1200 healthy controls with a set of questionnaire. The second stage is a diagnostic test, aims to indentify and ...
The nine-item Patient Health Questionnaire-9 (PHQ-9) and the shorter PHQ-2 and PHQ-8 are commonly recommended for depression screening. Thus, the primary objectives of our IPD meta-analyses are to determine the diagnostic accuracy of the PHQ-9, PHQ-8, and PHQ-2 to detect MDD among ...
A 'positive' test, (consistent with the presence of MDD) was defined as an MDDScore of 50 or greater. For the Pilot Study, 36 MDD patients were recruited along with 43 non-depressed subjects. In this sample, the test demonstrated a sensitivity and specificity of 91.7% and 81.3%, ...
Meta-analysis and meta-regression calculated odds ratios to test the association between early improvement and baseline severity and outcomes. Adults with acute MDD according to DSM-IV, DSM-III-R or DSM-III receiving antidepressant medication in RCT setting.n = 17 studies included in sen...
The nine-item Patient Health Questionnaire-9 (PHQ-9) and the shorter PHQ-2 and PHQ-8 are commonly recommended for depression screening. Thus, the primary objectives of our IPD meta-analyses are to determine the diagnostic accuracy of the PHQ-9, PHQ-8, and PHQ-2 to detect MDD among ...
The nine-item Patient Health Questionnaire-9 (PHQ-9) and the shorter PHQ-2 and PHQ-8 are commonly recommended for depression screening. Thus, the primary objectives of our IPD meta-analyses are to determine the diagnostic accuracy of the PHQ-9, PHQ-8, and PHQ-2 to detect MDD among ...
Finally, when examining the PDSQ MDD subscale, we combined patients with MDD, bipolar I depression, bipolar II depression, and 4 patients who met full criteria for MDD but also had nonbizarre delusions outside of the mood episode. According to DSM-IV, these 4 patients were diagnosed as ...
The first stage of this study is a case–control study, aims to explore the risk factors for developing MDD and then define the subtypes of MDD using 1200 MDD patients and 1200 healthy controls with a set of questionnaire. The second stage is a diagnostic test, aims to indentify and ...
Bayes factor evidence for a difference was decisive in the group with SZ (BF10 = 111.94) and strong in the group with MDD (BF10 = 8.45). The group with BPD did not differ significantly from the unaffected group in the composite neuropeptide score (Dunnett post hoc t test, 1.50 ...