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The underlying molecular feature responsible for this specific appearance are the loss of function mutations and a subsequent loss of heterozygosity (LOH) of CDH1, the gene coding for E-cadherin, and occasionally epigenetic silencing4,5. E-cadherin is expressed at the cell membrane where it ...
MiRNAs, non-coding RNAs of 21–24 nucleotides in length, regulate gene expression by promoting or inhibiting mRNA degradation and translation. miRNAs have been shown to be implicated in the biological processes and pathogenesis of AS and NASH. Several studies have summarized the roles of miRNAs in...
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MiRNAs, non-coding RNAs of 21–24 nucleotides in length, regulate gene expression by promoting or inhibiting mRNA degradation and translation. miRNAs have been shown to be implicated in the biological processes and pathogenesis of AS and NASH. Several studies have summarized the roles of miRNAs in...
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According to the National Comprehensive Cancer Network guidelines for genetic assessment (https://www.nccn.org),22 initial BRCA testing should be performed for breast cancer, followed by advanced next-generation sequencing analysis using GRCh38 if the BRCA result is negative. The protein-coding region...
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The SERPINA7 mutations due to the substitution of amino acids or truncation of the mature protein result in TBG deficiency, reduced affinity for T4, or both [253]. Various reports have described how these mutations in the coding and non-coding regions of the SERPINA7 gene result in complete...