New effective medications are under development and some emerging targeted therapies for FOP are already researched in clinical trials. The ACVR1 gene (Ensembl: ENSG00000115170) is located on chromosome 2 consisting of 9 coding exons [8]. It codes a bone morphogenetic protein (BMP) type I ...
created a mouse model with the H3f3b gene which codes for histone variant H3.3 deleted. The lack of the H3f3b gene produces faulty sperm cells, fewer germ cells, and testicular atrophy, which leads to infertility [184]. Vieweg et al. (2015) found aberrant histone acetylation of H4K12 at...
The third method is the so called drop-in approach that includes a test vehicle having the same pad frame of the product and containing sensitive SoC (System on Chip) modules directly accessible by the test equipments for yield monitoring. For instance, the drop-in includes static RAMs, analog...
Since the CNVs identified herein have been associated with the etiology of schizophrenia, methods for identifying agents that modulate the activity of the genes and their encoded products containing such CNVs should result in the generation of efficacious therapeutic agents for the treatment of this con...
OBD a critical tool used for emission control in today's automobiles. OBD generates fault codes when any system/component non-compliance is detected. Commercially available tools fetch fault codes from OBD and are providing only limited information/access of basic data to engineers. These tools are...