However, hypogammaglobulinemia secondary to cancer, chemotherapy, immunosuppressive therapy, chromosomal alterations, and protein-losing diseases is a widely recognized condition. The clinical relevance of seco
Finally, the infections risk may not be related only to the neu- tropenia: the best example is the WHIM syndrome, which combines lymphopenia, hypogammaglobulinemia and very high susceptibility to human papillovirus infec- tions [191]. Outcome: morbidity related to extra-hematopoietic involvement ...
A distinct pathophysiological mechanism underlies anti-glutamic acid decarboxylase (GAD) AIE. Glutamic acid decarboxylase catalyses the direct transformation of the strongest excitatory neurotransmitter glutamic acid into the strongest inhibitory neurotransmitter gamma-amino-butyric acid (GABA) with pyridoxine (v...
Clarification regarding whether the hypogammaglobulinemia is secondary or primary is important because this has implications for evaluation and management. Prior receipt of immunosuppressive medications and/or presence of conditions associated with SHG development, including protein loss syndromes, are ...
The remaining seven patients had prolonged hypogammaglobulinemia after the age of four and had significantly lower memory B cell subsets compared to the HC. On followhese patients had not experienced recurrent infections or autoimmunity. Re〆valuation of patients' B cell subsets six years later ...
Molecular diagnosis of Ureaplasma urealyticum septic arthritis in a patient with hypogammaglobulinemia. Arthritis Rheum 1992;35: 443-8.Lee AH, Ramanujam T, Ware P, Edelstein PH, Brooks JJ, Freundlich B, et al. Molecular diagnosis of Ureaplasma urealyt- icum septic arthritis in a patient with...
Mohiuddin MS, Abbott JK, Hubbard N, Torgerson TR, Ochs HD, Gelfand EW. Diagnosis and evaluation of primary panhypogammaglobulinemia: a molecular and genetic challenge. J Allergy Clin Immunol. 2013;131(6):1717–8.Mohiuddin MS, Abbott JK, Hubbard N, Torgerson TR, Ochs HD, Gelfand EW. ...
A putative diagnosis is initially made after exclusion of other causes of hypogammaglobulinemia while a definitive diagnosis of THI can only be made a posteriori in patients with normalization of IgG levels. The aim of this study is to characterize clinical and immunological features of children ...
Mohiuddin MS, Abbott JK, Hubbard N, Torgerson TR, Ochs HD, Gelfand EW. Diagnosis and evaluation of primary panhypogammaglobulinemia: a molecular and genetic challenge. J Allergy Clin Immunol. 2013;131(6):1717–8.Mohiuddin MS, Abbott JK, Hubbard N, Torgerson TR, Ochs HD, Gelfand EW. ...
B cell lymphomaDIFFUSE large B-cell lymphomasAGAMMAGLOBULINEMIADIAGNOSISINFECTION25% had low Ig, defined as any deficiency, 18% had low IgG, 37% lymphopenia and 13% both low Ig and lymphopenia. Furthermore, hypogammaglobulinemia was associated with an increased risk of severe infections,...