APCR values of the patients with homozygous factor V Leiden mutation (70.4+/-13.5 s) were significantly lower (p<0.001) in comparison to the subjects with the heterozygous mutation (87.6+/-13.4 s). The assay is highly sensitive (98.7%) and specific (91.9%) for the screening of factor V...
physicians could change the diagnosis name associated with a code when the name was inappropriate. That this option was used shows the advantage of being able to change diagnoses.
It is usually caused by a mutation that alters the binding site of factor V for activated protein C (factor V Leiden) and occurs in 5% of the general population and in 20% to 40% of unselected patients with DVT.37 Other blood abnormalities that result in an increased risk of DVT ...
Patients with a history of known, documented thrombophilia (Factor V Leiden, Prothrombin 20210 gene mutation, deficiencies of AT III, protein C or S, or homocysteinemia) are also excluded. Following informed consent, blood is drawn (˜20-40 ml) pre-operatively, on post-operative day (POD)...
Kind Code: A1 Abstract: Specific polymorphisms in BChE gene have been found which allow determining whether a patient suffers from dementia with Lewy bodies (DLB), and allow distinguishing it from Alzheimer's disease. The invention provides an in vitro method for the diagnosis of DLB comprising...
The sensitivity and specificity of the APCR testing reached to 100% below the cut-off value of 120 s among the patients with homozygous factor V Leiden mutation. Therefore, this method could help the desired effective optimal screening strategy for the laboratory search of hereditary thrombophilia ...