This invention pertains to the use of fused bicycle heterocyclic adducts of thiohydroxy pyridines or pyrimidines as diacylglycerol O-acyltransferase 1 (DGAT-1) inhibitors to treat hyperlipidiemias and various diseases and disorders associated therewith. Other conditions also be ameliorated or avoided, ...
Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step in triglyceride synthesis. Findings from genetically modified mice as well as pharmacological studies suggest that inhibition of DGAT1 is a promising strategy for the treatment of obesity ...
O-Acyltransferase Expression Constructs—Human DGAT1 and ACAT2 cDNAs were expressed from the cytomegalovirus promoter of pCR3.1 (Invitrogen) with ∼25 bp of 5′- and 3′-untranslated sequences (38). ACAT1 was isolated by reverse transcription-PCR from mRNA extracted from the human macrophage ce...
Diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes the acyl-CoA-dependent acylation of sn-1, 2-diacylglycerol to generate triacylglycerol and CoA. The deduced amino acid sequence of cDNAs encoding DGAT1 from plants and mammals exhibit a hydrophilic N-terminal region followed by a number ...
13 Sulfolipid 2′-O-acyltransferase no candidate 14 Monogalactosyldiacylglycerol synthase MGD1 EDP09106 15 Digalactosyldiacylglycerol synthase DGD1 EDP08851 16 Acyl-ACP thioesterase FAT1 EDP08596 CYTOSOLIC PATHWAYS 17 Long-chain acyl-CoA synthetase LCS1 EDO96800 LCS2 EDP08946 18 Glycerol-3-P: ...
These compounds and pharmaceutical compositions containing them can be used to treat diseases such as obesity, type II diabetes and metabolic syndrome.克里斯托夫·米舒CN101171231A * Apr 27, 2006 Apr 30, 2008 霍夫曼-拉罗奇有限公司 二酰基甘油酰基转移酶抑制剂...
Xanthohumols,diacylglycerolacyltransferase inhibitors,from Humulus lupulus. Tabata N,Ito M,Tomoda H,et al. Phyto-chem . 1997Tabata N, Ito M, Tomoda H, et al. Xanthohumols,diacylycerol acyltransrerase inhibitors, from Humulus lupulus [J]. Phytochemistry, 1997, (46): 683-687....
Recent progress on acyl CoA: lysophospholipid acyltransferase research J. Lipid Res, 50 (2009), pp. S46-S51 View PDFView articleCrossrefView in ScopusGoogle Scholar 29. J.G. Donaldson Phospholipase D in endocytosis and endosomal recycling pathways Biochim Biophys Acta, 1791 (2009), pp. 845-84...
5B). The C20:1n-9 and C20:1n-7 then become the preferred substrates for esterification to the 2,3 positions of alkyl glycerol by unidentified 1-alkylglycerol: acyltransferase for the synthesis of ADG. The reasons for incorporating specific very long chain monounsaturated fatty acids in the 1-...
It is an object to provide a novel diacylglycerol acyltransferase. The present invention relates to a diacylglycerol acyltransferase, a polynucleotide encoding the same, and so on. The present invention provides a polynucleotide comprising the nucleotide sequence of, e.g., SEQ ID NO: 1 or 4, a ...